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  1. Research

    Elevated expression of TIGIT on CD3+CD4+ T cells correlates with disease activity in systemic lupus erythematosus

    It is well-known that lymphocytes play an important role in systemic lupus erythematosus (SLE). T cell immunoreceptor with Ig and immunoreceptor tyrosine-based inhibitory domains (TIGIT) is one of immunosuppre...

    Qing Luo, Jianqing Ye, Lulu Zeng, Xue Li, Le Fang, Beihua Ju, Zikun Huang and Junming Li

    Allergy, Asthma & Clinical Immunology 2017 13:15

    Published on: 28 February 2017

  2. Review

    Gene therapy for primary immune deficiencies: a Canadian perspective

    The use of gene therapy (GT) for the treatment of primary immune deficiencies (PID) including severe combined immune deficiency (SCID) has progressed significantly in the recent years. In particular, long-term...

    Xiaobai Xu, Chetankumar S. Tailor and Eyal Grunebaum

    Allergy, Asthma & Clinical Immunology 2017 13:14

    Published on: 27 February 2017

  3. Case Report

    An avoidable cause of thymoglobulin anaphylaxis

    Thymoglobulin® (anti-thymocyte globulin [rabbit]) is a purified pasteurised, gamma immune globulin obtained by immunisation of rabbits with human thymocytes. Anaphylactic allergic reactions to a first injectio...

    S. Brabant, A. Facon, F. Provôt, M. Labalette, B. Wallaert and C. Chenivesse

    Allergy, Asthma & Clinical Immunology 2017 13:13

    Published on: 23 February 2017

  4. Letter to the editor

    Allergic rhinitis: the eligible candidate to mite immunotherapy in the real world

    As standard drug treatment of allergic rhinitis (AR) is not completely satisfactory, allergen immunotherapy (AIT) represents the only current treatment with the potential to modify the natural history. House d...

    Giorgio Ciprandi, Valentina Natoli, Paola Puccinelli and Cristoforo Incorvaia

    Allergy, Asthma & Clinical Immunology 2017 13:11

    Published on: 21 February 2017

  5. Letter to the editor

    Primum non nocere—first do no harm. And then feed peanut

    The Addendum Guidelines for the Prevention of Peanut Allergy in the United StatesReport of the NIAID-Sponsored Expert Panel were developed to build on previous food allergy guidelines after several key studies d...

    Kyla Jade Hildebrand, Elissa Michele Abrams, Timothy K. Vander Leek, Julia Elizabeth Mainwaring Upton, Douglas P. Mack, Linda Kirste, Christine McCusker and Sandeep Kapur

    Allergy, Asthma & Clinical Immunology 2017 13:7

    Published on: 8 February 2017

  6. Research

    Prevalence of allergen sensitization in 1000 adults in Saskatchewan

    The prevalence of sensitization varies geographically based on multiple environmental factors including humidity. The aim of this study was to determine the prevalence of atopy in symptomatic adults. More impo...

    Stacey D. Lok, Beth E. Davis and Donald W. Cockcroft

    Allergy, Asthma & Clinical Immunology 2017 13:9

    Published on: 8 February 2017

  7. Research

    Day-time variation of serum periostin in asthmatic adults treated with ICS/LABA and adults without asthma

    We aimed to determine the effect of sampling time during the day on serum periostin levels in adult participants with and without asthma.

    Rachel Caswell-Smith, Terrianne Cripps, Thom Charles, Alexander Hosking, Meghana Handigol, Cecile Holweg, John Matthews, Mark Holliday, Corentin Maillot, James Fingleton, Mark Weatherall, Richard Beasley and Irene Braithwaite

    Allergy, Asthma & Clinical Immunology 2017 13:8

    Published on: 8 February 2017

  8. Research

    Prediction of clinical peanut allergy status among children in Hamilton, Ontario using chart review data collected during 2012–2015

    Peanut sensitization does not necessarily indicate clinical peanut allergy, and uncertainty as to whether or not there is true peanut allergy can lead to increased anxiety and decreased quality of life for pat...

    Elizabeth Simms, Gary Foster, Katherine Arias, Mark Larché, Tosha Freitag, Tina Walker, Susanna Goncharova, Andrea Marrin, Andreas Freitag, Manel Jordana and Susan Waserman

    Allergy, Asthma & Clinical Immunology 2017 13:10

    Published on: 8 February 2017

  9. Short report

    Hereditary angioedema: health-related quality of life in Canadian patients as measured by the SF-36

    Hereditary angioedema (HAE) is a rare but serious condition characterized by recurrent spontaneous attacks of angioedema affecting superficial tissues of upper respiratory and gastrointestinal tracts. The pote...

    Nina Lakhani Jindal, Elaine Harniman, Nieves Prior, Elia Perez-Fernandez, Teresa Caballero and Stephen Betschel

    Allergy, Asthma & Clinical Immunology 2017 13:4

    Published on: 19 January 2017

  10. Case report

    Airway autoimmune responses in severe eosinophilic asthma following low-dose Mepolizumab therapy

    Anti-interleukin (IL)-5 monoclonal antibodies as an eosinophil-depleting strategy is well established, with Mepolizumab being the first biologic approved as an adjunct treatment for severe eosinophilic asthma.

    Manali Mukherjee, Hui Fang Lim, Sruthi Thomas, Douglas Miller, Melanie Kjarsgaard, Bruce Tan, Roma Sehmi, Nader Khalidi and Parameswaran Nair

    Allergy, Asthma & Clinical Immunology 2017 13:2

    Published on: 6 January 2017

  11. Position article and guidelines

    Addendum guidelines for the prevention of peanut allergy in the United States: report of the National Institute of Allergy and Infectious Diseases-sponsored expert panel

    Food allergy is an important public health problem because it affects children and adults, can be severe and even life-threatening, and may be increasing in prevalence. Beginning in 2008, the National Institut...

    Alkis Togias, Susan F. Cooper, Maria L. Acebal, Amal Assa’ad, James R. Baker, Lisa A. Beck, Julie Block, Carol Byrd-Bredbenner, Edmond S. Chan, Lawrence F. Eichenfield, David M. Fleischer, George J. Fuchs, Glenn T. Furuta, Matthew J. Greenhawt, Ruchi S. Gupta, Michele Habich…

    Allergy, Asthma & Clinical Immunology 2017 13:1

    Published on: 6 January 2017

  12. Review

    Asthma and the microbiome: defining the critical window in early life

    Asthma is a chronic inflammatory immune disorder of the airways affecting one in ten children in westernized countries. The geographical disparity combined with a generational rise in prevalence, emphasizes th...

    Leah T. Stiemsma and Stuart E. Turvey

    Allergy, Asthma & Clinical Immunology 2017 13:3

    Published on: 6 January 2017

  13. Case report

    Polyethylene glycol as a cause of anaphylaxis

    Polyethylene glycols (PEGs) or macrogols are polyether compounds and are widely used as additives in pharmaceuticals, cosmetics, and food.

    Katharina Wylon, Sabine Dölle and Margitta Worm

    Allergy, Asthma & Clinical Immunology 2016 12:67

    Published on: 13 December 2016

  14. Case report

    Anaphylaxis to supplemental oral lactase enzyme

    Anaphylactic reactions involving IgE mediated hypersensitivity have been frequently reported for a number of uncommon foods. However, cases of anaphylaxis to over the counter vitamins and oral supplements have...

    M. R. Voisin and R. Borici-Mazi

    Allergy, Asthma & Clinical Immunology 2016 12:66

    Published on: 13 December 2016

  15. Meeting abstracts

    AllerGen’s 8th research conference

    Marie-Claire Arrieta, Andrea Arevalos, Leah Stiemsma, Marta E. Chico, Carlos Sandoval, Minglian Jin, Jens Walter, Phil Cooper, Brett Finlay, Emilie Bernatchez, Matthew J. Gold, Anick Langlois, Pascale Blais-Lecours, Caroline Duchaine, David Marsolais, Kelly M. McNagny…

    Allergy, Asthma & Clinical Immunology 2016 12(Suppl 2):63

    Published on: 8 December 2016

    This article is part of a Supplement: Volume 12 Supplement 2

  16. Research

    Gene mutations responsible for primary immunodeficiency disorders: A report from the first primary immunodeficiency biobank in Iran

    Primary immunodeficiency (PID) is a heterogeneous group of inheritable genetic disorders with increased susceptibility to infections, autoimmunity, uncontrolled inflammation and malignancy. Timely precise diag...

    Saba Sheikhbahaei, Roya Sherkat, Dirk Roos, Majid Yaran, Somayeh Najafi and Alireza Emami

    Allergy, Asthma & Clinical Immunology 2016 12:62

    Published on: 2 December 2016

  17. Research

    Analysis of feline and canine allergen components in patients sensitized to pets

    Component resolved allergen diagnosis allows for a precise evaluation of the sensitization profiles of patients sensitized to felines and canines. An accurate interpretation of these results allows better insi...

    Natalia Ukleja-Sokołowska, Ewa Gawrońska-Ukleja, Magdalena Żbikowska-Gotz, Ewa Socha, Kinga Lis, Łukasz Sokołowski, Andrzej Kuźmiński and Zbigniew Bartuzi

    Allergy, Asthma & Clinical Immunology 2016 12:61

    Published on: 30 November 2016

  18. Research

    Prevalence of beta-lactam allergy: a retrospective chart review of drug allergy assessment in a predominantly pediatric population

    Research suggests that 90% of patients labeled beta-lactam allergic are able to tolerate penicillins following further assessment. This study aims to define and describe the frequency of true beta-lactam aller...

    Elissa M. Abrams, Andrew Wakeman, Tom V. Gerstner, Richard J. Warrington and Alexander G. Singer

    Allergy, Asthma & Clinical Immunology 2016 12:59

    Published on: 29 November 2016

  19. Review

    Lymphocyte Kv1.3-channels in the pathogenesis of chronic obstructive pulmonary disease: novel therapeutic implications of targeting the channels by commonly used drugs

    In patients with chronic obstructive pulmonary disease (COPD), over-activated T-lymphocytes produce pro-inflammatory cytokines and proliferate in situ in the lower airways and pulmonary parenchyma, contributin...

    Itsuro Kazama and Tsutomu Tamada

    Allergy, Asthma & Clinical Immunology 2016 12:60

    Published on: 29 November 2016

  20. Research

    Usefulness of component resolved analysis of cat allergy in routine clinical practice

    Cat allergy is of great importance, and its prevalence is increasing worldwide. Cat allergens and house dust mite allergens represent the major indoor allergens; however, they are ubiquitous. Cat sensitization...

    Katharina Eder, Sven Becker, Marion San Nicoló, Alexander Berghaus and Moritz Gröger

    Allergy, Asthma & Clinical Immunology 2016 12:58

    Published on: 15 November 2016

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