Long-term benefits of omalizumab in a patient with severe non-allergic asthma
© Menzella et al; licensee BioMed Central Ltd. 2011
Received: 21 January 2011
Accepted: 24 May 2011
Published: 24 May 2011
Currently, omalizumab is indicated for the treatment of patients with severe allergic uncontrolled asthma despite optimal therapy.
We studied a 52-year-old man who has been suffering from severe non allergic steroid-resistant asthma with increased levels of total IgE and a lot of comorbidity. After a 3 years long treatment with omalizumab, he presented a significant improvement in disease control in terms of hospitalizations, exacerbation, quality of life and lung function with good safety profile.
Our case shows, after a long follow-up, how omalizumab can be effective in a severe form of non-atopic asthma. It is therefore hoped that further studies can identify indicators that are able to give to clinicians information about patients who can be responsive to monoclonal anti-IgE antibody even if non allergic.
Patients with severe asthma often have a poor control of their disease; they represent the subgroup that absorbs most of the costs [1, 2]; for these reasons it has given rise to the need to get new drugs able to improve control. The only biological drug available for the treatment of severe asthma is omalizumab. A number of clinical trials have been performed in order to evaluate either the efficacy or the safety of the above-mentioned drug: the results showed that this molecule is able to significantly improve asthma control and quality of life, with an excellent safety profile [3–5].
Actually, as set by the European Medicine Agency (EMA)  and GINA Guidelines , in Europe omalizumab is indicated as an add-on therapy aimed at improving asthma control in adult and adolescent patients (12 years of age and above) with severe persistent allergic asthma who have a positive skin test or in vitro reactivity to a perennial aeroallergen and who show reduced lung function (FEV1 <80%) as well as frequent daytime symptoms or night-time awakenings and who have had multiple documented severe asthma exacerbations despite daily high-dose inhaled corticosteroids, plus a long-acting inhaled beta2-agonist. This treatment option is limited to patients with baseline IgE level of 30 to 1.500 IU/ml and body weight of 20 to 150 kg.
In this study we describe the case of a man suffering from severe non-allergic steroid-resistant asthma associated with important comorbidity in which omalizumab induced an extraordinary improvement of symptoms, health-related quality of life (HRQoL), exacerbations and lung function.
In May 2006 a Caucasian 52-year-old man came to our observation because of severe persistent asthma not controlled despite an extensive therapy (formoterol 18 mcg/day; budesonide 640 mcg/day; tiotropium bromide 18 mcg/day), oral steroids (prednisone 25 mg/day). The patient has a history of 2 severe exacerbations with hospitalization, several mild and moderate exacerbations (4-5/year) treated with increase of systemic steroids, frequent nocturnal awakenings (2-3 per night) and daily use of salbutamol as rescue medication (3-4 times/day) , frequent nocturnal awakenings (2-3 per night) and daily use of albuterol as rescue medication (3-4 times/day) with side effects related to inhaled steroid (oral candidiasis) and LABA (tachycardia) that had prevented him from increasing the dosage of these drugs.
Omalizumab treatment effectiveness
Exacerbation mild + moderate
5 for year
Even the skin prick test for common aeroallergens was negative. The allergens we performed (both for cutaneous and serological tests) were: grasses, parietaria officinalis, ragweed, mugwort, plantain, birch, cypress, walnut, dust mites, molds (Aspergillus Fumigatus, Alternaria, Cladosporium, Penicillium), cat and dog epithelium.
We used the Asthma Quality of Life Questionnaire (AQLQ)  to assess the patient's QoL with an initial score of 1,71 points, indicating a poor HRQoL [Table 1]. Given the poor asthma control, the severe obstruction and total IgE, we hypothesized that treatment with omalizumab could be effective, despite the absence of sensitization to inhalant allergens.
The patient signed the informed consent and started the treatment in July 2006 (300 mg every 15 days subcutaneously). An improvement in symptoms of asthma control was evident after only 16 weeks of treatment; the patient had no exacerbation. The lung function parameters were essentially unchanged but the AQLQ score increased to 3.23 [Table 1].
In order to evaluate the efficacy of omalizumab, the Global Evaluation of Treatment Effectiveness scales (GETE) [3, 9, 10] was used and the result was good. After 32 weeks of treatment the discontinuation of systemic steroid and tiotropium was possible. In that interval, there had been no exacerbations; spirometry showed a slight worsening (FEV1 1.33 l), while the AQLQ score was further improved (4.62). The GETE was excellent. The patient was followed until July 2010 and in that range he had only two mild relapses and no hospitalization. The AQLQ score arrived at 5.43 confirming a marked improvement in the quality of life; spirometry showed a discrete increase (FEV1 1.70 l; 53% of predicted) compared to baseline (FEV1 +15%). The GETE was confirmed excellent [Table 1].
Finally, the assay of serum IgE at the end of follow-up was 419 IU/ml, with an increase compared to baseline.
According to current guidelines, omalizumab is a safe and effective add-on treatment which, in suitable patients , allows them to obtain better control of asthma by reducing the number of exacerbations and the use of steroids and improving the quality of life [3, 4].
Actually, one only report  concerns the effectiveness of this drug in a patient with non-allergic asthma (who had high total IgE). Several authors showed that the different phenotypes of asthma have several likeness, with similar cytokine and cellular patterns both in allergic and non-allergic asthma [12, 13]. Therefore, IgE may have a key role in the inflammatory cascade (even in the absence of a proved aeroallergen) contributing to bronchial hyper reactivity and remodeling in asthma. Also, it is well known that higher values of IgE are associated with higher hyper reactivity and more severe obstruction .
However, it was shown that the block of free IgE is not the only pharmacological effect of omalizumab, as it also promotes the down-regulation of the expression of the high-affinity receptor FcεRI, causing a further reduction of IgE on the cell surface [14, 15].
Also, a study by Berger and cohautors showed that the in vitro incubation with omalizumab of bronchial tissue from asthmatic patients, inhibits specific and aspecific bronchial hyper-responsiveness. This effect should be related to the inhibition of bronchial mast-cells degranulation .
Based on these considerations, we hypothesized that treatment with omalizumab in our patient could be effective, in spite of what is indicated by the guidelines and the manufacturer.
The clinical and instrumental data show a significant improvement in disease control in terms of hospitalizations and exacerbations. In order to evaluate the effectiveness at 32 weeks and at 3 years, we used the Global Evaluation of Treatment Effectiveness scale (GETE) [3, 9, 10]. The evaluation is performed independently by both investigator and patient using the same 5 point scale. This scale ranges from excellent through good, moderate, and poor to worsening. A good or excellent response is suggested as a means of defining a patient who has responded to treatment. In our patient the GETE rating at 3 years was excellent, confirming the effectiveness of omalizumab.
Health-related quality of life (HRQoL) was assessed by means of the AQLQ score . The AQLQ is composed of 32 questions which cover four domains: activity limitation, symptoms, environmental stimuli and emotional function. Subjects recall their experiences during the previous 2 weeks and score a number of asthma-related problems on a 7-point scale from 1 (maximum impairment) to 7 (no impairment). We used an overall summary index, which is the mean of the responses to the 32 items (total AQLQ score). The AQLQ was found to be valid, reproducible and responsive to change over time and a change in questionnaire score of 0.5 or more points has been determined to be the minimal clinically important difference . In our patient the quality of life improved significantly, with the AQLQ score progressively increasing over time. The lung function parameters were stable during the first months, showing a rise after four years. This could be explained by the bronchial remodelling caused by the long-standing ashtma, which needed several months of therapy to appreciate an improvement.
In our study, it is possible that specific allergic sensitivity was simply not identified, as the range of potential allergenic agents is considerably larger than current diagnostic reagents can address, so false-negative allergen-skin-test results are likely to happen.
Also, in this patient the contribution of placebo effects cannot be excluded. However, improvements were seen in objective parameters such as lung function and number of exacerbations as well as symptom improvement.
The possibility that the improvement is related to a greater surveillance is unlikely as it was previously followed consistently with good compliance. In addition, the timing are closely related with the administration of omalizumab.
About the increase of total IgE, it is well-known that patients treated with omalizumab may exhibit reduction of serum free IgE levels with increased total IgE due to the formation of IgE anti-IgE small immune complexes, which have a longer half-life than free IgE [17, 18]. However, this increase has not pathological significance.
In conclusion, our work shows after a long follow-up the effectiveness of omalizumab with a good safety profile in a severe form of non-atopic asthma with increased levels of total IgE. It is therefore hoped that further studies identify new indicators that can give to clinicians information about asthmatic patients who can be responsive to monoclonal anti-IgE antibody even if non allergic.
Written informed consent was obtained from the patient for publication of this case report.
The Centre the authors belong to participated in the last International Clinical Trial on omalizumab (CIGE025A2425) as National Coordinating Centre for Italy.
Asthma Quality of Life Questionnaire
Forced Expiratory Volume in 1 Second
Forced Ventilatory Capacity
Global Evaluation of Treatment Effectiveness
Global Initiative for Asthma
Quality of Life
- National Heart, and Blood Institute: Morbidity and mortality: 2002. 2002, Bethesda (MD) National Heart, Lung, and Blood Institute
- European Lung White Book: The first comprehensive survey on respiratory health in Europe. European Respiratory Society. Edited by: Loddenkemper R, Gibson GJ, Sybille Y. 2003, Sheffield: ERSJ, 16-25.
- Humbert M, Beasley R, Ayres J, Slavin R, Hébert J, Bousquet J, Beeh KM, Ramos S, Canonica GW, Hedgecock S, Fox H, Blogg M, Surrey K: Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE. Allergy. 2005, 60 (3): 309-16. 10.1111/j.1398-9995.2004.00772.x.View ArticlePubMed
- Rodrigo GJ, Neffen H, Castro-Rodriguez JA: Efficacy and safety of subcutaneous omalizumab versus placebo ad add on therapy to corticosteroids for children and adults with asthma: a systematic review. Chest. 2011, 139 (1): 28-35. 10.1378/chest.10-1194.View ArticlePubMed
- Walker S, Monteil M, Phelan K, Lasserson TJ, Walters EH: Anti-IgE for chronic asthma in adults and children. Cochrane Database of Systematic Reviews. 2006, CD003559-2
- European Medicine Agency (EMA)- Xolair. [http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000606/human_med_001162.jsp&murl=menus/medicines/medicines.jsp&jsenabled=true]
- GINA Global Strategy for Asthma Management and Prevention, 2006 NHI Publications No 02-3659. GINA update. 2009, [http://www.ginasthma.org]
- Juniper EF, Guyatt GH, Ferrie PJ, Ferrie PJ, Griffith LE, Townsend M: Measuring quality of life in asthma. Am Rev Respir Dis. 1993, 147: 832-8.View ArticlePubMed
- Lloyd Andrew, Turk Florian, Leighton Trevor, Canonica GW: Psychometric evaluation of Global Evaluation of Treatment Effectiveness: a tool to assess patients with moderate-to-severe allergic asthma. Journal of Medical Economics. 2007, 10 (3): 285-296. 10.3111/13696990701478856.View Article
- Brusselle G, Michils A, Louis R, Dupont L, Van de Maele B, Delobbe A, Pilette C, Lee CS, Gurdain S, Vancayzeele S, Lecomte P, Hermans C, MacDonald K, Song M, Abraham I: "Real-life" effectiveness of omalizumab in patients with severe persistent allergic asthma: The PERSIST study. Respir Med. 2009, 103 (11): 1633-42. 10.1016/j.rmed.2009.06.014.View ArticlePubMed
- Van den Berge M, Pauw RG, de Monchy JGR, van Minnen CA, Postma DS, Kerstjens HA: Beneficial effects of treatment with anti-IgE antibodies (omalizumab) in a patient with severe asthma and negative skin-prick test results. Chest. 2011, 139: 190-193. 10.1378/chest.10-0128.View ArticlePubMed
- Humbert M, Durham SR, Kimmitt P, Powell N, Assoufi B, Pfister R, Menz G, Kay AB, Corrigan CJ: Elevated expression of messenger ribonucleic acid encoding IL-13 in the bronchial mucosa of atopic and non atopic subjects with asthma. J Allergy Clin Immunol. 1997, 99 (5): 657-665. 10.1016/S0091-6749(97)70028-9.View ArticlePubMed
- Beeh KM, Ksoll M, Buhl R: Elevation of total serum immunoglobulin E is associated with asthma in non allergic individuals. Eur Respir J. 2000, 16 (4): 609-614. 10.1034/j.1399-3003.2000.16d07.x.View ArticlePubMed
- Holgate ST, Djukanovic R, Casale T, Bousquet J: Anti-immunoglobulin E treatment with omalizumab in allergic diseases: an update on anti-inflammatory activity and clinical efficacy. Clin Exp Allergy. 2005, 35: 408-416. 10.1111/j.1365-2222.2005.02191.x.View ArticlePubMed
- MacGlashan DW, Bochner BS, Adelman DC, Jardieu PM, Togias A, McKenzie-White J, Sterbinsky SA, Hamilton RG, Lichtenstein LM: Down-regulation of FceRI expression on human basophils during in vivo treatment of atopic patients with anti-IgE antibody. J Immunol. 1997, 158: 1438-45.PubMed
- Berger P, Scotto-Gomez E, Molimard M, Marthan R, Le Gros V, Tunon-de-Lara JM: Omalizumab decreases non-specific airway hyperresponsiveness. Allergy. 2007, 62: 154-161.View ArticlePubMed
- Hayashi N, Tsukamoto Y, Sallas WM, Lowe PJ: A mechanism-based binding model for the population pharmacokinetics and pharmacodynamics of omalizumab. Br J Clin Pharmacol. 2006, 63: 548-61.PubMed CentralView ArticlePubMed
- Hamilton RG, Marcotte GV, Saini SS: Immunological methods for quantifying free and total serum IgE levels in allergy patients receiving omalizumab (Xolair) therapy. J Immunol Methods. 2005, 303: 81-91. 10.1016/j.jim.2005.06.008.View ArticlePubMed
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