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  1. Research

    Day-time variation of serum periostin in asthmatic adults treated with ICS/LABA and adults without asthma

    We aimed to determine the effect of sampling time during the day on serum periostin levels in adult participants with and without asthma.

    Rachel Caswell-Smith, Terrianne Cripps, Thom Charles, Alexander Hosking, Meghana Handigol, Cecile Holweg, John Matthews, Mark Holliday, Corentin Maillot, James Fingleton, Mark Weatherall, Richard Beasley and Irene Braithwaite

    Allergy, Asthma & Clinical Immunology 2017 13:8

    Published on: 8 February 2017

  2. Research

    Prediction of clinical peanut allergy status among children in Hamilton, Ontario using chart review data collected during 2012–2015

    Peanut sensitization does not necessarily indicate clinical peanut allergy, and uncertainty as to whether or not there is true peanut allergy can lead to increased anxiety and decreased quality of life for pat...

    Elizabeth Simms, Gary Foster, Katherine Arias, Mark Larché, Tosha Freitag, Tina Walker, Susanna Goncharova, Andrea Marrin, Andreas Freitag, Manel Jordana and Susan Waserman

    Allergy, Asthma & Clinical Immunology 2017 13:10

    Published on: 8 February 2017

  3. Short report

    Hereditary angioedema: health-related quality of life in Canadian patients as measured by the SF-36

    Hereditary angioedema (HAE) is a rare but serious condition characterized by recurrent spontaneous attacks of angioedema affecting superficial tissues of upper respiratory and gastrointestinal tracts. The pote...

    Nina Lakhani Jindal, Elaine Harniman, Nieves Prior, Elia Perez-Fernandez, Teresa Caballero and Stephen Betschel

    Allergy, Asthma & Clinical Immunology 2017 13:4

    Published on: 19 January 2017

  4. Case report

    Airway autoimmune responses in severe eosinophilic asthma following low-dose Mepolizumab therapy

    Anti-interleukin (IL)-5 monoclonal antibodies as an eosinophil-depleting strategy is well established, with Mepolizumab being the first biologic approved as an adjunct treatment for severe eosinophilic asthma.

    Manali Mukherjee, Hui Fang Lim, Sruthi Thomas, Douglas Miller, Melanie Kjarsgaard, Bruce Tan, Roma Sehmi, Nader Khalidi and Parameswaran Nair

    Allergy, Asthma & Clinical Immunology 2017 13:2

    Published on: 6 January 2017

  5. Position article and guidelines

    Addendum guidelines for the prevention of peanut allergy in the United States: report of the National Institute of Allergy and Infectious Diseases-sponsored expert panel

    Food allergy is an important public health problem because it affects children and adults, can be severe and even life-threatening, and may be increasing in prevalence. Beginning in 2008, the National Institut...

    Alkis Togias, Susan F. Cooper, Maria L. Acebal, Amal Assa’ad, James R. Baker, Lisa A. Beck, Julie Block, Carol Byrd-Bredbenner, Edmond S. Chan, Lawrence F. Eichenfield, David M. Fleischer, George J. Fuchs III, Glenn T. Furuta, Matthew J. Greenhawt, Ruchi S. Gupta, Michele Habich…

    Allergy, Asthma & Clinical Immunology 2017 13:1

    Published on: 6 January 2017

  6. Review

    Asthma and the microbiome: defining the critical window in early life

    Asthma is a chronic inflammatory immune disorder of the airways affecting one in ten children in westernized countries. The geographical disparity combined with a generational rise in prevalence, emphasizes th...

    Leah T. Stiemsma and Stuart E. Turvey

    Allergy, Asthma & Clinical Immunology 2017 13:3

    Published on: 6 January 2017

  7. Case report

    Polyethylene glycol as a cause of anaphylaxis

    Polyethylene glycols (PEGs) or macrogols are polyether compounds and are widely used as additives in pharmaceuticals, cosmetics, and food.

    Katharina Wylon, Sabine Dölle and Margitta Worm

    Allergy, Asthma & Clinical Immunology 2016 12:67

    Published on: 13 December 2016

  8. Case report

    Anaphylaxis to supplemental oral lactase enzyme

    Anaphylactic reactions involving IgE mediated hypersensitivity have been frequently reported for a number of uncommon foods. However, cases of anaphylaxis to over the counter vitamins and oral supplements have...

    M. R. Voisin and R. Borici-Mazi

    Allergy, Asthma & Clinical Immunology 2016 12:66

    Published on: 13 December 2016

  9. Meeting abstracts

    AllerGen’s 8th research conference

    Marie-Claire Arrieta, Andrea Arevalos, Leah Stiemsma, Marta E. Chico, Carlos Sandoval, Minglian Jin, Jens Walter, Phil Cooper, Brett Finlay, Emilie Bernatchez, Matthew J. Gold, Anick Langlois, Pascale Blais-Lecours, Caroline Duchaine, David Marsolais, Kelly M. McNagny…

    Allergy, Asthma & Clinical Immunology 2016 12(Suppl 2):63

    Published on: 8 December 2016

    This article is part of a Supplement: Volume 12 Supplement 2

  10. Research

    Gene mutations responsible for primary immunodeficiency disorders: A report from the first primary immunodeficiency biobank in Iran

    Primary immunodeficiency (PID) is a heterogeneous group of inheritable genetic disorders with increased susceptibility to infections, autoimmunity, uncontrolled inflammation and malignancy. Timely precise diag...

    Saba Sheikhbahaei, Roya Sherkat, Dirk Roos, Majid Yaran, Somayeh Najafi and Alireza Emami

    Allergy, Asthma & Clinical Immunology 2016 12:62

    Published on: 2 December 2016

  11. Research

    Analysis of feline and canine allergen components in patients sensitized to pets

    Component resolved allergen diagnosis allows for a precise evaluation of the sensitization profiles of patients sensitized to felines and canines. An accurate interpretation of these results allows better insi...

    Natalia Ukleja-Sokołowska, Ewa Gawrońska-Ukleja, Magdalena Żbikowska-Gotz, Ewa Socha, Kinga Lis, Łukasz Sokołowski, Andrzej Kuźmiński and Zbigniew Bartuzi

    Allergy, Asthma & Clinical Immunology 2016 12:61

    Published on: 30 November 2016

  12. Research

    Prevalence of beta-lactam allergy: a retrospective chart review of drug allergy assessment in a predominantly pediatric population

    Research suggests that 90% of patients labeled beta-lactam allergic are able to tolerate penicillins following further assessment. This study aims to define and describe the frequency of true beta-lactam aller...

    Elissa M. Abrams, Andrew Wakeman, Tom V. Gerstner, Richard J. Warrington and Alexander G. Singer

    Allergy, Asthma & Clinical Immunology 2016 12:59

    Published on: 29 November 2016

  13. Review

    Lymphocyte Kv1.3-channels in the pathogenesis of chronic obstructive pulmonary disease: novel therapeutic implications of targeting the channels by commonly used drugs

    In patients with chronic obstructive pulmonary disease (COPD), over-activated T-lymphocytes produce pro-inflammatory cytokines and proliferate in situ in the lower airways and pulmonary parenchyma, contributin...

    Itsuro Kazama and Tsutomu Tamada

    Allergy, Asthma & Clinical Immunology 2016 12:60

    Published on: 29 November 2016

  14. Research

    Usefulness of component resolved analysis of cat allergy in routine clinical practice

    Cat allergy is of great importance, and its prevalence is increasing worldwide. Cat allergens and house dust mite allergens represent the major indoor allergens; however, they are ubiquitous. Cat sensitization...

    Katharina Eder, Sven Becker, Marion San Nicoló, Alexander Berghaus and Moritz Gröger

    Allergy, Asthma & Clinical Immunology 2016 12:58

    Published on: 15 November 2016

  15. Research

    Prospective evaluation of testing with baked milk to predict safe ingestion of baked milk in unheated milk-allergic children

    Cow’s milk allergy is one of the most common food allergies affecting young children. A subset of milk-allergic individuals can eat baked milk without allergic symptoms which is beneficial in terms of prognost...

    Allison Kwan, Maria Asper, Sasson Lavi, Elana Lavine, David Hummel and Julia E. Upton

    Allergy, Asthma & Clinical Immunology 2016 12:54

    Published on: 24 October 2016

  16. Research

    Predictors of allergen sensitization in Singapore children from birth to 3 years

    Immune responses in allergic diseases begin with allergen sensitization, which usually occurs in childhood. Allergen sensitization involves a complex interplay of genetic and environmental factors, and sensiti...

    Evelyn Xiu Ling Loo, Jordan Zheng Ting Sim, Anne Goh, Oon Hoe Teoh, Yiong Huak Chan, Seang Mei Saw, Kenneth Kwek, Peter D. Gluckman, Keith M. Godfrey, Hugo Van Bever, Yap Seng Chong, Bee Wah Lee, Michael S. Kramer and Lynette Pei-chi Shek

    Allergy, Asthma & Clinical Immunology 2016 12:56

    Published on: 24 October 2016

  17. Research

    Th17 responses are not altered by natural exposure to seasonal allergens in pollen-sensitive patients

    Allergic rhinitis affects 10–30 % of the global population and this number is likely to increase in the forthcoming years. Moreover, it commonly co-exists with allergic asthma as a chronic allergic respiratory...

    Agata Schramm, Barbara Jasiewicz-Honkisz, Grzegorz Osmenda, Grzegorz Wilk, Mateusz Siedlinski, Agnieszka Sagan, Pawel T. Matusik, Joanna Maciag, Tomasz Sliwa, Marta Czesnikiewicz-Guzik and Tomasz P. Mikolajczyk

    Allergy, Asthma & Clinical Immunology 2016 12:55

    Published on: 24 October 2016

  18. Research

    Clinical validation of controlled exposure to birch pollen in the Environmental Exposure Unit (EEU)

    The Environmental Exposure Unit (EEU) in Kingston, Ontario, Canada is a controlled allergen challenge facility (CACF) that has been previously clinically validated for the use of ragweed and grass pollen in cl...

    Anne K. Ellis, Mena Soliman, Lisa M. Steacy, Daniel E. Adams, Barnaby Hobsbawn and Terry J. B. Walker

    Allergy, Asthma & Clinical Immunology 2016 12:53

    Published on: 19 October 2016

  19. Review

    Genetic and epigenetic studies of atopic dermatitis

    Atopic dermatitis (AD) is a chronic inflammatory disease caused by the complex interaction of genetic, immune and environmental factors. There have many recent discoveries involving the genetic and epigenetic ...

    Lianghua Bin and Donald Y. M. Leung

    Allergy, Asthma & Clinical Immunology 2016 12:52

    Published on: 19 October 2016

  20. Review

    Air pollution, epigenetics, and asthma

    Exposure to traffic-related air pollution (TRAP) has been implicated in asthma development, persistence, and exacerbation. This exposure is highly significant as large segments of the global population resides...

    Hong Ji, Jocelyn M. Biagini Myers, Eric B. Brandt, Cole Brokamp, Patrick H. Ryan and Gurjit K. Khurana Hershey

    Allergy, Asthma & Clinical Immunology 2016 12:51

    Published on: 19 October 2016

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