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Featured Research: Better determining the role of TNF-α in chronic spontaneous urticaria

A new study investigates the important but unclear role of TNF-α in chronic spontaneous urticaria, confirming CSU is associated with activation of the TNF-α signalling pathway but crucially not the sFas/FasL system suggesting it is the pro-inflammatory function of TNF-α at play in CSU.

Featured Supplement: Practical guide for allergy and immunology in Canada 2018

An extensive update to the prominent and widely-popular Practical Guide for Allergy and Immunology in Canada published in 2011, this broad-ranging supplement is designed to provide all healthcare professionals with a comprehensive, yet easy-to-follow, series of peer-reviewed articles focussed on all of the common conditions dealt with in the field of allergy and immunology.


  1. Content type: Review


    Authors: Amin Kanani, Robert Schellenberg and Richard Warrington

  2. Content type: Review


    Authors: Peter Small and Harold Kim

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Aims and scope

Allergy, Asthma & Clinical Immunology (AACI), the official journal of the Canadian Society of Allergy and Clinical Immunology (CSACI), is an open access journal that encompasses all aspects of diagnosis, epidemiology, prevention and treatment of allergic and immunologic disease.

AACI reports on basic research and clinically applied studies in the following areas and other related topics: asthma and occupational lung disease, rhinoconjunctivitis and rhinosinusitis, drug hypersensitivity, allergic skin diseases, urticaria and angioedema, venom hypersensitivity, anaphylaxis and food allergy, immunotherapy, immune modulators and biologics, immune deficiency and autoimmunity, T cell and B cell functions, regulatory T cells, natural killer cells, mast cell and eosinophil functions, complement abnormalities.

Editorial Board


Richard Warrington, University of Manitoba, Canada

Associate Editors

Harold Kim, University of Western Ontario & McMaster University, Canada
Rajesh Kumar, Ann & Robert H. Lurie Children's Memorial Hospital, USA
Jean Marshall, Dalhousie University, Canada
Harissios Vliagoftis, University of Alberta, Canada
Wade Watson, Dalhousie University, Canada

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About the CSACI

AACI is the official journal of the Canadian Society of Allergy and Clinical Immunology (CSACI). The CSACI is the largest national professional medical specialty organization in Canada representing allergists, asthma specialists, clinical immunologists, allied health professionals and others with a special interest in the research and treatment of allergic diseases.

The CSACI was founded in 1945 to fulfill the following goals: improving the standards of teaching and the practice of allergy and clinical immunology; fostering co-operation between those engaged in the study and practice of allergy and clinical immunology; encourage research in the field of allergy and clinical immunology.

The CSACI represents over 475 (Canadian and international) members who are from all parts of the country including rural areas, cities, community hospitals and academic university teaching centres. The CSACI remains committed to supporting allergists and clinical immunologists in maintaining the pre-eminence of both research and education in Canada. Moving forward, the CSACI will support these aims to ensure that high quality health care is available to all our patients throughout our communities.

Editor's profile

Professor Richard Warrington

Dr Warrington is Professor and Head of Allergy and Clinical Immunology at the University of Manitoba in Winnipeg, Canada. He received his medical degree from the Royal London Hospital, London, England in 1968, and moved to St John’s, Newfoundland in 1969 to help found the new Medical School at Memorial University. He received his PhD in immunology from Memorial University, in 1973. He trained in allergy & clinical immunology at the University of Manitoba until 1976, when he joined the Section of Allergy & Clinical Immunology in the Department of Medicine, which he has headed since 1982. From 1983 to 1996, Dr Warrington directed the Rheumatic Disease Unit Research Laboratory at the University of Manitoba.


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