Association of the Frequency of Respiratory Illness in Early Childhood with a Change in the Distribution of Blood Lymphocyte Subpopulations

Table 3 Association between Lymphocytes and Illness

		Unadjusted Estimate*		Adjusted Estimate^†
Lymphocyte	Correlation (r)	Effect (B)	p Value	Effect (B)	p Value
(% indicates proportion of cells with that marker)
Total lymphocytes	-0.06367	-0.00230	0.6087	-0.00583	0.2149
% CD3/CD4⁺*	-0.18932	-0.03977	0.1087	-0.02070	0.4068
%CD3/CD8⁺	0.23017	0.05067	0.0535	0.03720	0.1588
%CD4/CD38^+†	0.17652s	0.03567	0.1352	0.04918	0.0510
%CD4/HLA-DR⁺	0.16187	0.00861	0.1774	0.00830	0.2412
%CD4/CD38⁺/HLA-DR⁺	0.0333	0.00111	0.7824	-0.00135	0.7566
%CD8/CD38⁺	0.26042	0.07976	0.0261	0.09751	0.0136
%CD8/HLA-DR⁺	0.09073	0.01598	0.4518	0.00493	0.8263
%CD8/CD38⁺/HLA-DR⁺	0.09125	0.01585	0.4525	0.00336	0.8780
%CD4/CD25⁺	-0.03003	-0.00219	0.8009	-0.00049135	0.9575
%CD4/CD69⁺	0.1319	0.00517	0.2659	0.00643	0.1958
%CD8/CD25⁺	-0.01634	-0.00076856	0.8908	0.00186	0.7562
%CD8/CD69⁺	0.10676	0.00310	0.3687	0.00393	0.2955
%CD4/CD45RA⁺	-0.01446	-0.00226	0.9034	-0.00554	0.7711
%CD4/CD45RA⁺/CD62L⁺	-0.00767	-0.00148	0.9490	-0.00364	0.8789
%CD8/CD45RA⁺	0.0289	0.00546	0.8082	0.02100	0.3590
%CD8/CD45RA⁺/CD62L⁺	0.01099	0.00325	0.9270	0.02944	0.4032
%CD4/CD45RO⁺	0.30264	0.10651	0.0098	0.13033	0.0048
%CD8/CD45RO⁺	0.21943	0.07640	0.0640	0.09587	0.0359
%CD4/CD29⁺	0.02811	0.00644	0.8173	0.01390	0.5441
%CD8/CD29⁺	0.0559	0.01215	0.6408	0.01344	0.6391

*Lymphocyte = illness (note: B value is that corresponding to illness).
^†Lymphocyte = illness + parents with university education + hours/week cared for outside home + hours/week of environmental tobacco smoke + ever water damage or mould in bedroom + parental history of asthma or allergy.

ISSN: 1710-1492