Table 1 CD4+ T Cells with Regulatory Activity
Regulatory T Cell | Characteristics |
|---|---|
Treg | CD25+ foxp3+ thymus derived |
| Â | Not dependent on IL-10 for biologic activity |
| Â | Mediates self-tolerance; prevents autoimmune disease |
| Â | Not likely to be relevant to acquired tolerance to allergens |
Th3 | Characterized by TGF-β (±IL-10) production |
| Â | Mediates mucosal tolerance/antigen-specific IgA production |
| Â | Not relevant to allergy or immunotherapy |
Tr1 | Peripheral-derived regulatory T cells |
|  | IL-10 responsible for biologic activity (±TGF-β) |
| Â | Possibly derived from Th1- or Th2-like lymphocytes or natural T cells |
| Â | CD25 expression (reflecting activation) |
| Â | Foxp3 negative |
| Â | Proposed mechanism of immunotherapy |