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Table 2 RR for asthma hospitalization in childhood according to birth weight, gestational age, and fetal growth

From: Birth weight, gestational age, fetal growth and childhood asthma hospitalization

Fetal development variables

Cases

Cumulative incidence (%)

Crude RR

Adjusted RR* (95% CI)

Birth weight

    

  <1000 g

542

8.35

3.03

2.33 (2.14-2.53)

  1000-1499 g

897

5.93

2.21

1.81 (1.68-1.95)

  1500-1999 g

1,423

4.51

1.69

1.48 (1.40-1.57)

  2000-2499 g

3,823

3.67

1.38

1.33 (1.28-1.38)

  2500-2999 g

14,992

2.98

1.12

1.15 (1.12-1.17)

  3000-3499 g

41,716

2.73

1.02

1.05 (1.04-1.07)

  3500-3999 g

44,451

2.67

1

1 (ref)

  4000-4499 g

19,371

2.73

1.02

0.99 (0.97-1.01)

  4500-4999 g

4,037

2.89

1.08

1.03 (0.99-1.06)

  ≥5000 g

531

2.87

1.08

1.01 (0.92-1.11)

Birth weight per 1000-g decrease

-

-

1.18

1.17 (1.15-1.18)

Gestational age

    

  22-28 weeks

737

8.07

2.89

2.26 (2.10-2.43)

  29-32 weeks

1,416

5.16

1.88

1.63 (1.54-1.73)

  33-36 weeks

6,471

3.50

1.28

1.26 (1.22-1.29)

  37-38 weeks

23,062

2.98

1.09

1.10 (1.09-1.12)

  39-41 weeks

91,055

2.73

1

1 (ref)

  42-45 weeks

9,042

2.37

0.86

0.98 (0.95-1.00)

GA per reduced week

-

-

1.07

1.05 (1.04-1.06)

Fetal growth

    

  SGA

4,878

3.38

1.23

1.20 (1.16-1.24)

  AGA

121,741

2.76

1

1 (ref)

  LGA

5,164

3.18

1.15

1.05 (1.02-1.09)

Z-score per decreased of SD

-

-

1.00

1.03 (1.02-1.04)

  1. *Adjusted for country of residence, maternal age at delivery, maternal social status, parity, mode of delivery, sex of the child, calendar year of birth and family history of asthma.