From: Birth weight, gestational age, fetal growth and childhood asthma hospitalization
Fetal development variables | Asthma hospitalization | Asthma medication | ||||||
---|---|---|---|---|---|---|---|---|
Cases | Cumulative incidence (%) | Crude RR | Adjusted RR* (95% CI) | Cases | Cumulative incidence (%) | Crude RR | Adjusted RR* (95% CI) | |
Birth weight | ||||||||
<1000 g | 94 | 13.58 | 2.64 | 2.82 (2.12-3.74) | 306 | 34.06 | 2.00 | 1.94 (1.75-2.15) |
1000-1499 g | 184 | 9.01 | 1.91 | 1.71 (1.42-2.06) | 624 | 27.12 | 1.63 | 1.51 (1.39-1.65) |
1500-1999 g | 318 | 7.76 | 1.64 | 1.41 (1.21-1.64) | 1,107 | 24.23 | 1.45 | 1.37 (1.28-1.47) |
2000-2499 g | 812 | 6.87 | 1.46 | 1.30 (1.17-1.44) | 2,950 | 22.30 | 1.34 | 1.29 (1.22-1.36) |
2500-2999 g | 2,919 | 5.29 | 1.12 | 1.10 (1.03-1.18) | 11,142 | 18.79 | 1.13 | 1.11 (1.07-1.16) |
3000-3499 g | 8,099 | 5.01 | 1.06 | 1.07 (1.02-1.13) | 30,145 | 16.89 | 1.02 | 1.01 (0.98-1.04) |
3500-3999 g | 8,500 | 4.72 | 1 | 1 (ref) | 32,242 | 16.43 | 1 | 1 (ref) |
4000-4499 g | 4,045 | 4.89 | 1.04 | 1.01 (0.95-1.08) | 14,984 | 16.55 | 1.00 | 0.99 (0.95-1.02) |
4500-4999 g | 869 | 4.74 | 1.01 | 1.02 (0.92-1.12) | 3,165 | 16.59 | 1.00 | 1.00 (0.95-1.05) |
≥5000 g | 135 | 5.56 | 1.18 | 1.15 (0.91-1.45) | 463 | 16.48 | 1.01 | 0.99 (0.89-1.08) |
Birth weight per 1000-g decrease | - | - | 1.17 | 1.15 (1.11-1.19) | - | - | 1.13 | 1.11 (1.10-1.13) |
Gestational age | ||||||||
22-28 weeks | 129 | 11.72 | 2.34 | 2.37 (1.87-2.99) | 412 | 30.69 | 1.86 | 1.78 (1.64-1.94) |
29-32 weeks | 301 | 8.65 | 1.79 | 1.49 (1.29-1.72) | 1,084 | 25.67 | 1.56 | 1.45 (1.36-1.54) |
33-36 weeks | 1,318 | 6.36 | 1.32 | 1.20 (1.10-1.30) | 5,021 | 21.90 | 1.33 | 1.26 (1.22-1.30) |
37-38 weeks | 4,464 | 5.67 | 1.17 | 1.14 (1.08-1.21) | 16,967 | 18.69 | 1.13 | 1.10 (1.08-1.13) |
39-41 weeks | 17,616 | 4.79 | 1 | 1 (ref) | 65,682 | 16.44 | 1 | 1 (ref) |
42-45 weeks | 2,147 | 4.61 | 0.96 | 0.94 (0.88-1.01) | 7,962 | 17.40 | 1.05 | 1.05 (0.95-1.16) |
GA per reduced week | - | - | 1.06 | 1.05 (1.04-1.06) | - | - | 1.04 | 1.04 (1.03-1.05) |
Birth weight for gestational age | ||||||||
SGA | 1,055 | 6.36 | 1.29 | 1.20 (1.10-1.31) | 3,776 | 21.15 | 1.25 | 1.19 (1.14-1.24) |
AGA | 23,784 | 4.94 | 1 | 1 (ref) | 89,263 | 17.02 | 1 | 1 (ref) |
LGA | 1,136 | 5.32 | 1.07 | 1.11 (0.99-1.24) | 4,089 | 17.34 | 1.02 | 1.04 (0.99-1.09) |
Z-score per decreased of SD | - | - | 1.03 | 1.01 (0.99-1.03) | - | - | 1.03 | 1.02 (1.01-1.03) |