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Table 3 Medications approved for short-term prophylaxis of HAE attacks

From: The prophylactic use of C1 inhibitor in hereditary angioedema patients undergoing invasive surgical procedures: a retrospective study

Short-term prophylaxis

Medication class

Example

Dose

Approval

Canada

US

Europe

C1 INH replacement (plasma derived)

Berinert

10 to 20 U/kg body weight or 1000 U IV*

  

✓

Cinryze

500-1500 U IV 1 hour prior to event

 

✓

✓

Attenuated androgens

Danazol

200 mg PO TID × 5-7 d before procedure, and 4 d post-procedure

 

✓

 
  1. Of note: androgens are contraindicated in: pregnancy, lactation, and growing children. They are also associated with severe side-effects.
  2. *Recommendation varies as dose yet to be fully investigated.