HRQL scores improve in caregivers of participants on mOIT and rush mOIT. Median HRQL score at baseline, 6-month follow-up, and 18-month follow-up are shown for the control group, mOIT group, and rush mOIT group. Whiskers represent minimum and maximum values. Median HRQL scores were 3.6, 4.4, 4.2 at baseline, 6 months, and 18 months, respectively, for the control group; 4.3, 2.4, 1.8 for the mOIT group; 3.9, 1.3, 0.8 for the rush mOIT group. ** p < 0.01, *** p = 0.001, **** p < 0.0001.