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Figure 5 | Allergy, Asthma & Clinical Immunology

Figure 5

From: Epigenetic regulation of asthma and allergic disease

Figure 5

Transgenerational amplification hypothesis. Panel A depicts a purely environmental model for the rise of atopic disease, in which a change in environment increases baseline genetic risk for the disease. Panel B depicts an epigenetic transgenerational inheritance model, in which a persistent change in environment does not only increase baseline risk but induces transmittable epigenetic changes leading to amplification of the phenotype with every subsequent generation. Return to a normal environment, will lead to resolution of the phenotype but only after 2 generations.

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