Figure 2

Multifactor dimensionality reduction test for the Arg16Gly and Gln27Glu polymorphisms in the ADRB2 gene in Asthma patients. A. Distribution of patients according to different genotype combinations for the clustering of Arg16Gly and Gln27Glu polymorphisms in the ADRB2 gene. Combinations of high risk are in gray and low risk are in white. The number in the figure represents the patients with a given genotype combination. For example, in the first square, 14 asthma patients (left column) and five healthy patients (right column) have the following genotype: AA for the Arg16Gly polymorphism and CC for the Gln27Glu polymorphism. In this case, the first column in each square represents the asthma patient group, and the second column represents healthy subjects. B. Dendrogram of the polymorphism interactions with respect to asthma presence. The same color in this case indicates linkage between the analyzed polymorphisms. C. Graph of entropy measuring the power of different polymorphisms and the interactions between them for the gene analyzed to explain the polymorphism-polymorphism association with asthma occurrence. The association is represented by 9.87% for the Arg16Gly polymorphism and 24.36% for the Gln27Glu polymorphism. The interaction between the polymorphisms accounts for -9.28% of the association. The protective genotypes in our samples are CG (for the Gln27Glu polymorphism) and AG or GG (for the Arg16Gly polymorphism).