Asthma: Gln27Glu and Arg16Gly polymorphisms of the beta2-adrenergic receptor gene as risk factors

Table 1 Association of ADRB2 polymorphisms [Arg16Gly (c.46A > G) and Gln27Glu (c.79C > G)] with asthma risk

Polymorphism	Genotype	Patient	Control	OR	95% CI
Arg16Gly (c.46A > G) ^1,2	Homozygous Arg16	28	9	6.782	3.07-16.03
	Heterozygous	38	59	1.056	0.61-1.81
	Homozygous Gly16	22	73	0.312	0.17-0.56
	Total	88	141
Gln27Glu(c.79C > G) ^3,4	Homozygous Gln27	41	41	2.120	1.22-3.71
	Heterozygous	36	11	8.096	3.90-17.77
	Homozygous Glu27	11	89	0.084	0.04-0.17
	Total	88	141

ADR2 = alpha2-adrenergic receptor; Arg = arginine; Gly = Glycine; Gln = Glutamine; Glu = Glutamic acid; A = Adenine; G = Guanine; T = Thymine; OR = Odds Ratio; CI = Confidence Interval.
Hardy-Weinberg equilibrium was calculated using the OEGE tool (http://www.oege.org/software/hardy-weinberg.html), being: (1 - patient) χ² = 1.54, p-value > 0.05; (2 - control) χ² = 0.48, p-value > 0.05; (3 - patient) χ² = 0.41, p-value > 0.05; (4 - control) χ² = 95.62, p-value < 0.001.
The OR was calculated using the Open-Epi tool (http://www.openepi.com). The OR and 95% CI values were obtained using the Mild-P test. For all data analyzed, α = 0.05 was used. The significant p-values are in bold.

ISSN: 1710-1492