Asthma: Gln27Glu and Arg16Gly polymorphisms of the beta2-adrenergic receptor gene as risk factors

Table 2 Association of ADRB2 polymorphism [Arg16Gly (c.46A > G) and Gln27Glu (c.79C > G)] combinations with asthma risk

Polymorphisms	Genotypes groups^*	Patient	Control	OR	95% CI
Gly16 – Gln27	1	19	23	1.411	0.71-2.79
Arg16 – Glu27	1	10	0	-	-
Arg16 – Gln27	0	14	5	5.108	1.82-16.37
Gly16 – Glu27	2	17	11	2.816	1.25-6.54
Het16 – Gln27	0	10	12	1.376	0.55-3.38
Het16 – Glu27	1	9	0	-	-
Het16 – Het27	0	3	60	0.048	0.01-0.14
Arg16 – Het27	0	4	4	1.627	0.36-7.39
Gly16 – Het27	1	2	26	0.1036	0.02-0.39

ADRB2 = alpha2-adrenergic receptor; Arg = arginine; Gly = Glycine; Gln = Glutamine; Glu = Glutamic acid; A = Adenine; G = Guanine; T = Thymine; Het = heterozygotes; OR = Odds Ratio; CI = Confidence Interval.
*The groups were created by counting each homozygous guanine allele at the Arg16Gly (c.46A > G) and Gln27Glu (c.79C > G) polymorphisms: (0) Arg16Arg + Gln27Gln genotype combination; (1) Gly16Gly or Glu27Glu genotype presence; (2) Gly16Gly + Glu27Glu genotype combination.
The OR was calculated using the Open-Epi tool (http://www.openepi.com). The OR and 95% CI values were obtained using the Mild-P test. For all data analyzed, α = 0.05 was used. The significant p-values are in bold.

ISSN: 1710-1492