Table 4 Association of asthma severity with ADRB2 polymorphisms [Arg16Gly (c.46A > G) and Gln27Glu (c.79C > G)]
From: Asthma: Gln27Glu and Arg16Gly polymorphisms of the beta2-adrenergic receptor gene as risk factors
Severity | Arg16Gly (c.46A > G) polymorphism | χ2 | p-value | ||||||
|---|---|---|---|---|---|---|---|---|---|
Arg16Arg | OR (95% CI) | Arg16Gly | OR (95% CI) | Gly16Gly | OR (95% CI) | Total | |||
Severe | 14 (37.8%) | 1.258 (0.508 - 3.114) | 3 (8.1%) | 0.25 (0.064 - 0.966) | 20 (54.1%) | 1.672 (0.698 - 4.003) | 37 (100%) | 4.674 | 0.322 |
Moderate | 7(33.3%) | 0.909 (0.319 - 2.587) | 5 (23.8%) | 1.625 (0.484 - 5.454) | 9 (42.9%) | 0.703 (0.259 - 1.906) | 21 (100%) | ||
Mild | 8 (32%) | 0.829 (0.306 - 2.246) | 7 (28%) | 2.431 (0.771 - 7.665) | 10 (40%) | 0.667 (0.258 - 1.726) | 25 (100%) | ||
Gln27Glu (c.79C > G) polymorphism | |||||||||
Gln27Gln | OR (95% CI) | Gln27Glu | OR (95% CI) | Glu27Glu | OR (95% CI) | Total | |||
Severe | 25 (67.6%) | 2.708 (1.099 - 6.674) | 3 (8.1%) | 0.182 (0.048 - 0.691) | 9 (24.3%) | 1.023 (0.372 - 2.812) | 37 (100%) | 8.285 | 0.082 |
Moderate | 10 (47.6%) | 0.701 (0.26 - 1.892) | 6 (28.6%) | 1.667 (0.534 - 5.197) | 5 (23.8%) | 0.979 (0.307 - 3.124) | 21 (100%) | ||
Mild | 10 (40%) | 0.438 (0.168 - 1.141) | 9 (36%) | 3.063 (1.037 - 9.041) | 6 (24%) | 0.9925 (0.331 - 2.973) | 25 (100%) | ||
Arg16Gly (c.46A > G) and Gln27Glu (c.79C > G) polymorphisms in combination* | |||||||||
0 | OR (95% CI) | 1 | OR (95% CI) | 2 | OR (95% CI) | Total | |||
Severe | 12 (32.4%) | 0.571 (0.232 - 1.406) | 21 (56.8%) | 1.706 (0.712 - 4.086) | 4 (10.8%) | 0.994 (0.247 - 4) | 37 (100%) | 1.908 | 0.753 |
Moderate | 9 (42.9%) | 1.188 (0.435 - 3.241) | 10 (47.6%) | 0.909 (0.338 - 2.448) | 2 (9.5%) | 0.827 (0.158 - 4.331) | 21 (100%) | ||
Mild | 12 (48%) | 1.626 (0.629 - 4.205) | 10 (40%) | 0.581 (0.224 - 1.504) | 3 (12%) | 1.182 (0.271 - 5.154) | 25 (100%) | ||