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Figure 1 | Allergy, Asthma & Clinical Immunology

Figure 1

From: B cell Semaphorin 4c expression mitigates the airway hyperresponsiveness and acute inflammation which characterize allergic airway disease

Figure 1

A-H. Sema4C localized at B cellular synapses for wild-type mice (WT). Immunofluorescence staining of B cells stimulated with CD40L, IL-4, and IL-21 for 24 hours (A-D), or 72 hours (E-H). I-L. Sema4C-/- (KO) B cells have aberrant actin cytoskeletal structural organization. M. KO mice have narrower airway diameter than WT mice. H&E staining of WT (n=6) and KO (n=5) lungs with Allergic Airway Disease (AAD). N. KO mice with AAD had a greater percentage of lung-infiltrating lymphocytes (CD4+ T cells, CD19+ B cells, and CD138+ plasma cells) than WT mice. Lymphocytes were recovered using Bronchoalveolar Lavage. E. KO mice with AAD had higher serum OVA-specific IgE levels than WT mice. F. KO mice with AAD had lower serum IL-10 levels than WT mice.

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