Amoxicillin rash in patients with infectious mononucleosis: evidence of true drug sensitization

Table 1 True sensitization to amoxicillin examined by in vivo cutaneous tests

Patient	Age (years)	Gender	Culprit drug	LTT results	Prick test results	Intradermal test results	Patch test results
1	15	female	amoxicillin/clavulanic acid	Negative	Negative	PPL 1:100 and 1:10 Positive	Not performed
2	19	female	amoxicillin	Negative	Negative	MDM undiluted Positive	Not performed
3	29	female	amoxicillin/clavulanic acid	Negative	Negative	PPL 1:10 Positive	Not performed
4	23	male	amoxicillin/clavulanic acid	Negative	Negative	MDM 1:100 and 1:10 Positive	Not performed
5	35	male	amoxicillin/clavulanic acid	Negative	Negative	Negative	Negative
6	24	female	amoxicillin/clavulanic acid	Negative	Negative	Negative	Negative
7	21	male	amoxicillin	Negative	Not performed	Not performed	Not performed
8	20	female	amoxicillin/clavulanic acid	Negative	Not performed	Not performed	Not performed
9	16	male	amoxicillin/clavulanic acid	Negative	Not performed	Not performed	Not performed
10	27	male	amoxicillin/clavulanic acid; cefixime	Positive: cefixime	Not performed	Not performed	Not performed

PPL: major determinant: benzylpenicilloyl poly-L-lysine.
MDM: minor determinant mix: sodium benzylpenicillin, benzylpenicilloic acid, sodium benzylpenicilloate.
Bold text: Verified sensitization to penicillin.
Tests were done in the following chronology: LTT → Prick test (non-diluted PPL) → Intradermal test (1:100 dilution of PPL, 1:10 dilution of PPL, non-diluted PPL) → Prick test (non-diluted MDM) → Intradermal test (1:100 dilution of MDM, 1:10 dilution of MDM, non-diluted MDM) → Patch test (culprit drug).

ISSN: 1710-1492