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Figure 1 | Allergy, Asthma & Clinical Immunology

Figure 1

From: Mechanisms of Degranulation in Neutrophils

Figure 1

Rho guanosine triphosphatase and SNAP receptor (SNARE) signalling pathways involved in Ca2+-dependent neutrophil degranulation. Receptor binding by a chemoattractant leads to G protein-coupled signal transduction (G protein-coupled receptor [GPCR]) through multiple overlapping intracellular pathways to regulate the selective release of neutrophil granules. Some of these pathways may be non-redundant, for example, through G protein-activated guanine nucleotide exchange factors (GEFs) to activate Rac2, which selectively mobilizes primary granules. ER = endoplasmic reticulum; fMLP = F-Met-Lev-Phe; IL = interleukin; InsP3 = inositol 1, 4, 5-triphosphate; LPTF = lactoperin; MMP = matrix metalloprotease; MPO = myeloperoxidase; VAMP = vesicle-associated membrane protein.

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