Figure 2

Tyrosine kinases associated with chemokine-induced neutrophil degranulation. Receptor binding leads to direct binding of the G protein-coupled receptor (GPCR) by β-arrestins, which also translocate to primary and secondary granules along with src family kinases Hck and Fgr. IL = interleukin; LTF = ; MAP = mitogen-activated protein; MMP = matrix metalloprotease; MPO = myeloperoxidase.