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Table 2 Classification of the Most Commonly Employed NSAIDs According to Their Inhibitory Effect on COX Isoenzymes

From: Clinical Management of Adult Patients with a History of Nonsteroidal Anti-Inflammatory Drug-Induced Urticaria/Angioedema: Update

COX-1/COX-2 inhibitors

   Salicylates (aspirin, diflunisal, salsalate)

   Oxicams (piroxicam)

   PAD (ibuprofen, naproxen, ketoprofen, fenprofen, flurbiprofen)

   Arylacetic acids (indomethacin, etodolac, sulindac, diclofenac, tolmetin)

   Fenamates (meclofenamate, mefenamic acid)

   Pyrrolopyrrole (ketorolac)

   Pyrazolones (phenylbutazone, oxyphenbutazone, feprazone, noramidopyrine)

Weak COX-1/COX-2 inhibitors

   Paracetamol

Preferential COX-2 inhibitors

   Nimesulide, meloxicam

Selective COX-2 inhibitors

   Coxibs (eg, etoricoxib, rofecoxib, celecoxib)

  1. COX = cyclooxygenase; NSAID = nonsteroidal anti-inflammatory drug;
  2. PAD = propionic acid derivatives.
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Allergy, Asthma & Clinical Immunology

ISSN: 1710-1492

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