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Table 2 Classification of the Most Commonly Employed NSAIDs According to Their Inhibitory Effect on COX Isoenzymes

From: Clinical Management of Adult Patients with a History of Nonsteroidal Anti-Inflammatory Drug-Induced Urticaria/Angioedema: Update

COX-1/COX-2 inhibitors
   Salicylates (aspirin, diflunisal, salsalate)
   Oxicams (piroxicam)
   PAD (ibuprofen, naproxen, ketoprofen, fenprofen, flurbiprofen)
   Arylacetic acids (indomethacin, etodolac, sulindac, diclofenac, tolmetin)
   Fenamates (meclofenamate, mefenamic acid)
   Pyrrolopyrrole (ketorolac)
   Pyrazolones (phenylbutazone, oxyphenbutazone, feprazone, noramidopyrine)
Weak COX-1/COX-2 inhibitors
   Paracetamol
Preferential COX-2 inhibitors
   Nimesulide, meloxicam
Selective COX-2 inhibitors
   Coxibs (eg, etoricoxib, rofecoxib, celecoxib)
  1. COX = cyclooxygenase; NSAID = nonsteroidal anti-inflammatory drug;
  2. PAD = propionic acid derivatives.