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Table 1 Summary of Main Epidemiologic Data

From: Nonsteroidal Anti-Inflammatory Drug Hypersensitivity in Preschool Children

 

References

In the general population, the incidence of NSAID hypersensitivity in young children is low, although it may equal that found in healthy adults

[5]

ADRs account for only 4.3% of general pediatric hospitalizations, but ASA-containing medications constitute approximately one-fifth of these and tend to cause clinically severe reactions

[6, 7]

About a third of children developing acute NSAID hypersensitivity in a medical setting are 6 years old or younger

[7, 8]

Atopy and allergic disease are the most significant risk factors for the development of NSAID hypersensitivity in young children (and older ones)

[14, 15]

The prevalence of NSAID hypersensitivity in atopic children is 2% but lower in the young age group and increases with age

[13]

The incidence of challenge-derived ASA hypersensitivity in asthmatics depends on the diagnostic protocol used

[9–12]

In the young age group, there is no female preponderance (like that seen in adults with ASA-sensitive asthma)

[15, 16]

Antipyretic doses of ibuprofen in young children do not seem to increase the risk of hospitalization due to asthma or bronchitis compared with acetaminophen

[17]

The risk of acute exacerbations in young asthmatic children during an acute illness is not increased by the use of antipyretic doses of ibuprofen

[18]

  1. ADR = adverse drug reaction; ASA = acetylsalicylic acid; NSAID = nonsteroidal anti-inflammatory drug.