From: Nonsteroidal Anti-Inflammatory Drug Hypersensitivity in Preschool Children
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In the general population, the incidence of NSAID hypersensitivity in young children is low, although it may equal that found in healthy adults | [5] |
ADRs account for only 4.3% of general pediatric hospitalizations, but ASA-containing medications constitute approximately one-fifth of these and tend to cause clinically severe reactions | |
About a third of children developing acute NSAID hypersensitivity in a medical setting are 6 years old or younger | |
Atopy and allergic disease are the most significant risk factors for the development of NSAID hypersensitivity in young children (and older ones) | |
The prevalence of NSAID hypersensitivity in atopic children is 2% but lower in the young age group and increases with age | [13] |
The incidence of challenge-derived ASA hypersensitivity in asthmatics depends on the diagnostic protocol used | |
In the young age group, there is no female preponderance (like that seen in adults with ASA-sensitive asthma) | |
Antipyretic doses of ibuprofen in young children do not seem to increase the risk of hospitalization due to asthma or bronchitis compared with acetaminophen | [17] |
The risk of acute exacerbations in young asthmatic children during an acute illness is not increased by the use of antipyretic doses of ibuprofen | [18] |