Table 2 Summary of Clinical Presentations of NSAID Hypersensitivity in Preschool Children

Nonspecific, cross-reactive, COX inhibitor related

   ASA-exacerbated respiratory disease (AERD)

[9–12, 32]

   Angioedema/urticaria in children with chronic urticaria

[33–37]

   Angioedema/urticaria in children without chronic urticaria

[15, 38–40]

   Mixed reactions (angioedema/urticaria and acute respiratory symptoms, bronchospasm)

[15, 41]

   The most common clinical manifestation of NSAID hypersensitivity at this age is facial angioedema with or without generalized urticaria

[13, 15]

Drug-specific, immune-mediated reactions

   Immediate single drug-mediated urticaria/angioedema

[38, 42]

   Delayed-type hypersensitivity reactions (eg, fixed drug eruptions and toxic epidermal necrolysis)

[38, 43–46]

No publications of ASA-/NSAID-induced aseptic meningitis or hypersensitivity pneumonitis were identified