Figure 4

DNA methylation silences gene expression by two mechanisms. A, Methylation interferes with binding of a transcription factor to its recognition element. B, Methylated DNA attracts methylated DNA binding proteins such as MeCP2, which recruits histone deacetylase (HDAC), corepressor Sin3A, histone methyltransferases such as SuV39, and methyl K9 H3-histone binding protein (HP1).