Patch Testing in Non-Immediate Drug Eruptions

Table 4 Drug Intradermal Testing

*Characteristics*	*ESCD*[6]	*ENDA*[7]
Time interval*	6 wk-6 mo	3 wk-3 mo
Site	Volar forearm skin	Volar forearm skin
Reagents	Sterile solutions (1/10,000 → 1/10) in phenolated saline or in 0.9% saline	Sterile solutions (1/100,000 → 1/1) in 0.9% saline (non-hydrosoluble drugs → in DMSO)
Amount	0.04 mL	0.02-0.05 mL
Reading	30 min, 6 h, D1, D7	20 min, D1, D3
Documentation/scoring	By measuring the diameter of the papule	Infiltrate erythema = positive reaction
Contraindications*	Erythema multiforme, SJS, TEN, leukocytoclastic vasculitis	None

D = day; DMSO = dimethyl sulphoxide; ENDA = European Network on Drug Allergy; ESCD = European Society of Contact Dermatitis; SJS = Stevens-Johnson syndrome; TEN = toxic epidermal necrolysis.
*Time interval between the complete healing of cutaneous adverse reactions and the allergologic evaluation.

ISSN: 1710-1492