Date | Person | Discovery |
---|---|---|
460 BC | Hippocrates | Described properties of powders derived from bark of white willow tree (Salix alba) |
1853 | Gerhardt | Created ASA by acetylation of phenolic hydroxyl group of salicylic acid |
1874 | Kolbe | Synthesis of salicylic acid, used as a painkiller, although with severe GI side effects |
1889 | Hoffman | Rediscovered the medicinal properties of ASA without GI irritation; mass marketing by Bayer |
1922 | Abrami and Lemoyez | Reported a case of anaphylaxis to 100 mg ASA |
1967 | Samter and Beers | Reported the phenomena of ASA intolerance, nasal polyposis, asthma |
1967 | Vanselow | Bronchial asthma induced by indomethacin |
1971 | Sir John Vane | Identified mechanism of action of ASA as inhibition of cyclooxygenase pathway |
1973 | Lockey et al | Reported mechanism of the mode of inheritance of AEA as autosomal recessive |
1980 | Stevenson | Reported successful desensitization to ASA |
1994 | Szczeklik | Reported eicosanoids (cysteinyl leukotrienes) in pathogenesis of AEA |