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Table 1 Historical Perspective of Aspirin and Aspirin-Exacerbated Asthma

From: Aspirin-Exacerbated Asthma

Date Person Discovery
460 BC Hippocrates Described properties of powders derived from bark of white willow tree (Salix alba)
1853 Gerhardt Created ASA by acetylation of phenolic hydroxyl group of salicylic acid
1874 Kolbe Synthesis of salicylic acid, used as a painkiller, although with severe GI side effects
1889 Hoffman Rediscovered the medicinal properties of ASA without GI irritation; mass marketing by Bayer
1922 Abrami and Lemoyez Reported a case of anaphylaxis to 100 mg ASA
1967 Samter and Beers Reported the phenomena of ASA intolerance, nasal polyposis, asthma
1967 Vanselow Bronchial asthma induced by indomethacin
1971 Sir John Vane Identified mechanism of action of ASA as inhibition of cyclooxygenase pathway
1973 Lockey et al Reported mechanism of the mode of inheritance of AEA as autosomal recessive
1980 Stevenson Reported successful desensitization to ASA
1994 Szczeklik Reported eicosanoids (cysteinyl leukotrienes) in pathogenesis of AEA
  1. AEA = aspirin-exacerbated asthma; ASA = acetylsalicylic acid; GI = gastrointestinal.