Figure 2

Three-dimensional structures of allergenic polcalcins. Monomeric birch Bet v 4, dimeric timothy grass Phl p 7, and tetrameric goosefoot Che a 3 represent 2EF-polcalcins from tree, grass, and weed pollen. Molecules are depicted in their "holo"-conformation with bound calcium ions illustrated as red balls. Secondary structure elements (A) are shown in green (α-helices) and yellow (β-sheets). The distribution of hydrophilic (blue) and hydrophobic (red) amino acids over the molecular surface is depicted in B. All models were obtained from the Protein Structure Database http://www.pdb.org/pdb/home/home.do and visualized with chimera http://www.cgl.ucsf.edu/chimera/