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Table 1 Pharmacokinetics of pasteurized pd C1-INH Concentrate (median values)

From: On demand treatment and home therapy of hereditary angioedema in Germany - the Frankfurt experience

  Incremental IVR
[%rise/U/kg bw]
Tmax
[hr]
T 1/2
[hr]
MRT
[hr]
AUC
[U*hr/mL]
Clearance
[mL/kg*hr]
Vss
[mL/kg]
Children on Demand n = 6 2.2 0.6 32.9 47.5 13.4 1.1 50.0
Adults on Demand n = 19 2.0 1.0 39.1 56.5 16.7 0.9 56.5
Adults IRT n = 15 2.9* 0.5 30.9** 44.6** 15.7 1.0 37.5***
  1. *p = 0.006, ** p = 0.052, *** p = 0.004, statistically significant differences of Adults IRT vs. Adults on demand
  2. IVR = in vivo recovery
  3. Tmax = Median time to maximum functional pd C1-INH level
  4. T1/2 = Terminal elimination half-life
  5. MRT = Mean residence time
  6. AUC = area under the curve
  7. Vss = Volume of distribution at steady state