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Table 1 Pharmacokinetics of pasteurized pd C1-INH Concentrate (median values)

From: On demand treatment and home therapy of hereditary angioedema in Germany - the Frankfurt experience

 

Incremental IVR

[%rise/U/kg bw]

Tmax

[hr]

T 1/2

[hr]

MRT

[hr]

AUC

[U*hr/mL]

Clearance

[mL/kg*hr]

Vss

[mL/kg]

Children on Demand n = 6

2.2

0.6

32.9

47.5

13.4

1.1

50.0

Adults on Demand n = 19

2.0

1.0

39.1

56.5

16.7

0.9

56.5

Adults IRT n = 15

2.9*

0.5

30.9**

44.6**

15.7

1.0

37.5***

  1. *p = 0.006, ** p = 0.052, *** p = 0.004, statistically significant differences of Adults IRT vs. Adults on demand
  2. IVR = in vivo recovery
  3. Tmax = Median time to maximum functional pd C1-INH level
  4. T1/2 = Terminal elimination half-life
  5. MRT = Mean residence time
  6. AUC = area under the curve
  7. Vss = Volume of distribution at steady state