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Table 4 Changes in exhaled nitric oxide (ENO), exhaled breath condensate (EBC) pH, and Alt a1-specific IgG4 in serum.

From: Effect of allergen-specific immunotherapy with purified Alt a1 on AMP responsiveness, exhaled nitric oxide and exhaled breath condensate pH: a randomized double blind study

 

Baseline

6 months

12 months

SIT group

   

   ENO, ppb

38.5 (27.3-54.6)

33.4 (25.2-44.4)

37.7 (29.5-48.0)

P

 

NS

NS

   EBC pH

7.43 (7.15-7.70)

6.91 (6.55-7.28)

7.57 (7.34-7.79)

P

 

< 0.05

NS

   Alt a1-specific IgG4, μg/ml

0.07 (0.03-0.11)

1.21 (0.69-1.73)

1.62 (1.02-2.22)

P

 

< 0.001

< 0.001

Placebo group

   

   ENO, ppb

40.4 (27.2-60.1)

32.1 (20.7-49.8)

37.0 (22.9-59.2)

P

 

NS

NS

   EBC pH

7.50 (7.24-7.77)

7.28 (6.97-7.59)

7.44 (7.21-7.67)

P

 

NS

NS

   Alt a1-specific IgG4, μg/ml

0.09 (0.06-0.12)

0.13 (0.07-0.18)

0.11 (0.07-0.15)

P

 

NS

NS

  1. Values are geometric means (95% confidence interval) for ENO and means (95% confidence interval) for EBC pH and Alt a1-spècific IgG4 values. P values are for the comparison with baseline values within groups. For abbreviations see Table 2.
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Allergy, Asthma & Clinical Immunology

ISSN: 1710-1492

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