Skip to main content

Table 3 Univariate analysis of the association of serum IgE and inhalant IgE screen positivity with IL13 and prenatal factors

From: Birth order modifies the effect of IL13 gene polymorphisms on serum IgE at age 10 and skin prick test at ages 4, 10 and 18: a prospective birth cohort study

 

Elevated serum IgE (age 10)

Inhalant IgE +ve (age 10)

 

n (%)

Exact

n (%)

Exact

Study Variables

N = 953

p-values

N = 952

p-values

rs1800925:

    

- TT/CT

108 (33.0)

0.086

117 (35.9)

0.191

- CC

173 (27.6)

 

197 (31.5)

 

rs2066960:

    

- AA/AC

62 (38.0)

0.011

58 (35.8)

0.410

- CC

219 (27.7)

 

256 (32.4)

 

rs20541:

    

- AA/GA

104 (32.6)

0.153

114 (35.9)

0.189

- GG

177 (27.9)

 

200 (31.6)

 

Birth order

    

- First

98 (27.7)

0.659

116 (32.8)

0.683

- Second

91 (30.0)

 

105 (34.8)

 

- Third or higher

64 (31.1)

 

64 (31.1)

 

- Latent

33 (47.8)

 

31 (44.9)

 

Family Social Status Cluster*

    

- High

22 (27.5)

0.328

22 (27.5)

0.363

- Middle

213 (28.9)

 

251 (34.1)

 

- Low

45 (35.2)

 

38 (29.7)

 

Environmental Tobacco Exposure**

    

- ETS-0

142 (31.5)

0.463

160 (35.6)

0.237

- ETS-1

85 (28.3)

 

89 (29.7)

 

- ETS-2

54 (27.1)

 

64 (32.2)

 

Gender

    

- Male

146 (30.5)

0.523

178 (37.2)

0.006

- Female

135 (28.5)

 

136 (28.7)

 

Prematurity (weeks)

    

- < 37

14 (53.9)

0.008

14 (53.9)

0.032

- ≥ 37

257 (28.4)

 

290 (32.1)

 

Low Birth Weight (g)

    

- < 2500

8 (24.2)

0.566

11 (33.3)

1.000

- ≥ 2500

265 (29.6)

 

291 (32.6)

 

Maternal History of Atopy

    

- Yes

100 (30.7)

0.600

125 (38.3)

0.013

- No

181 (28.9)

 

189 (30.2)

 

Maternal IgE

    

- > 100

65 (37.4)

0.009

73 (42.0)

0.002

- ≤ 100

130 (26.7)

 

140 (28.8)

 

Maternal Atopic Status***

    

- Definite

32 (30.5)

0.006

42 (40.0)

0.014

- Latent

33 (47.8)

 

31 (45.0)

 

- Probable

31 (26.3)

 

35 (30.0)

 

- None

99 (26.8)

 

105 (28.5)

 

Cord Serum IgE

    

- ≥ 0.5

34 (43.6)

0.004

37 (47.4)

0.005

- < 0.5

202 (27.4)

 

229 (31.0)

 
  1. *"Family social status cluster" is a composite variable derived from a combination of family income, parental occupation (socioeconomic status), and number of children in child's bedroom.
  2. ** ETS-0: mother did not smoke during pregnancy and children not exposed to household ETS; ETS-1: mother did not smoke during pregnancy, but children were exposed to household ETS; ETS-2: mother smoked during pregnancy and children were exposed to household ETS.
  3. ***Maternal atopic status was classified into Definite (elevated IgE, positive history); Latent (elevated IgE, negative history); Probable (normal IgE, positive history); and None (normal IgE, negative history).