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Table 5 Multivariate analysis of the association of elevated total serum IgE at age 10 (>200 kU/L) with IL13 polymorphisms and prenatal factors, stratified by birth order (n = 588) (PR = Prevalence Ratio)

From: Birth order modifies the effect of IL13 gene polymorphisms on serum IgE at age 10 and skin prick test at ages 4, 10 and 18: a prospective birth cohort study

 

1st Born

2nd Born

3rd and Higher

Study Variables

p

PR (95% CI)

p

PR (95% CI)

p

PR (95% CI)

 

n = 246

n = 212

n = 130

rs1800925:

      

-TT/CT vs. CC

0.007

1.73 (1.16, 2.57)

0.165

0.72 (0.45, 1.15)

0.794

0.93 (0.54, 1.61)

Gender (M vs. F)

0.499

1.14 (0.77, 1.71)

0.208

1.31 (0.86, 1.99)

0.350

1.28 (0.76, 2.15)

Smoke exposure*:

      

- ETS-1 vs. ETS-0

0.38

0.82 (0.53, 1.27)

0.175

0.70 (0.42, 1.17)

0.863

0.95 (0.54, 1.69)

- ETS-2 vs. ETS-0

0.064

0.54 (0.28, 1.04)

0.202

0.65 (0.33, 1.26)

0.536

0.79 (0.38, 1.66)

Family SES Cluster**:

      

- Low vs. High

0.198

1.88 (0.72, 4.91)

0.840

1.09 (0.49, 2.40)

0.589

0.72 (0.21, 2.41)

- Middle vs. High

0.767

1.13 (0.50, 2.54)

0.379

0.76 (0.41, 1.41)

0.915

1.05 (0.43, 2.54)

Gestational Age

0.173

0.93 (0.83, 1.03)

0.246

1.09 (0.94, 1.28)

0.582

1.06 (0.86, 1.31)

  1. * ETS-0: mother did not smoke during pregnancy and children not exposed to household ETS;
  2. ETS-1: mother did not smoke during pregnancy, but children were exposed to household ETS;
  3. ETS-2: mother smoked during pregnancy and children were exposed to household ETS.
  4. **"Family social status cluster" is a composite variable derived from a combination of family income, parental occupation (socioeconomic status), and number of children in child's bedroom.
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Allergy, Asthma & Clinical Immunology

ISSN: 1710-1492

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