Figure 2
From: VIP Regulates the Development & Proliferation of Treg in vivo in spleen
Wild-Type Thymus Associated With Lower Treg Numbers Than VIP-Treated VIP KO MiceA control mouse had intermediate levels of CD4+CD25+ thymic Tregs (384.14) compared to VIPKO (177.07) and VIP-treated VIP KO (596.09). This supports the concept that VIP can increase Treg centrally in thymus. Wild-type mice have fewer CD25+ cells compared VIP KO, suggesting that VIP is critical for suppression of CD25+ cell expression.