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Table 6 Studies Investigating Alternative Therapy Duration, Dose, or Formulation

From: Canadian clinical practice guidelines for acute and chronic rhinosinusitis

Agent Comparator Success Rate Side Effects
Duration
Azithromycin [96] Amoxicillin/clavulanate 88.8% and 84.9%, vs 84.9% Higher for amox/clav group
   500 mg/d    1500/375 mg/d   
   3 or 6 days    10 days   
Azithromycin [95] microspheres Levofloxacin 92.5% vs 92.8% Comparable
   2 g    500 mg/d   
   1 day    10 days   
Azithromycin [97] (meta-analysis) Amoxicillin, roxithromycin, cefaclor, erythromycin, amoxicillin/clavulanate, clarithromycin, penicillin Comparable Comparable
3 or 5 days    
Levofloxacin [98] Levofloxacin >90% for both groups Comparable
   750 mg/d    500 mg/d   
   5 days    10 days   
Gatifloxacin [99]* Amoxicillin/clavulanate 74% and 80%, vs 72% Comparable
   400 mg/d    1750/250 mg/d   
   5 or 10 days    10 days   
Gemifloxacin [100] Gemifloxacin 83.5% vs 84.2% Comparable
   320 mg/d    320 mg/d   
   5 days    7 days   
Dosing
Amoxicillin/clavulanate [101] Amoxicillin/clavulanate 88% vs 93% Comparable
   500/125 mg    875/125 mg   
   Every 8 hours    Every 12 hours   
Formulation
Clarithromycin [102] ER Amoxicillin/clavulanate 98% vs 97% Comparable
   1000 mg/d    1750/250 mg/d   
   14 days    14 days   
  1. *The fluoroquinolone, gatifloxacin was removed from the market following a study demonstrating potentially life-threatening glycemic events [103].
  2. ER, extended release.