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Figure 1 | Allergy, Asthma & Clinical Immunology

Figure 1

From: Mucosal exposure to cockroach extract induces allergic sensitization and allergic airway inflammation

Figure 1

Sensitization of Balb/c mice to CE allergens. A. Models of mucosal and intraperitoneal sensitization to CE. B. AHR (Penh) was assessed 24 h after the last challenge for mice sensitized using the short-term (saline-saline n = 5; saline-CE n = 5; CE-CE n = 5; left graph) long-term (saline-saline n = 6; CE-CE n = 13; middle graph) and intraperitoneal (saline-saline n = 5; CE-CE n = 8; right graph) models. Allergic airway inflammation was measured 24 h after AHR by assessing the total cell numbers in the BAL fluid for the (C) short-term (saline-saline n = 8; saline-CE n = 8; CE-CE n = 8), long-term (saline-saline n = 6; CE-CE n = 14) and intraperitoneal models (saline-saline n = 7; CE-CE n = 7) as well as total eosinophils in the BAL fluid (D) for the short term (saline-saline n = 8; saline-CE n = 8; CE-CE n = 8), long-term (saline-saline n = 6; CE-CE n = 14) and intraperitoneal models (saline-saline n = 7; CE-CE n = 7). The serum from these mice was analyzed using ELISA for the presence of cockroach-specific IgG1 antibodies (E) and cockroach-specific IgG2a antibodies (F) for the short term (saline-saline n = 3; saline-CE n = 5; CE-CE n = 3), long-term (saline-saline n = 5; CE-CE n = 12) and intraperitoneal models (saline-saline n = 7; CE-CE n = 7). Values shown in B-F are means ± SEM.

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