Figure 1
From: The concept of "compartment allergy": prilocaine injected into different skin layers
Clinical findings in delayed-type allergy against local anesthetics and histological picture of skin compartments showing the distribution of S-100 positive dendritic cells. a Delayed-type hypersensitivity reaction 4 days after superficial subcutaneous provocation with prilocaine (1 ml). Inlet Negative result after deep s.c. injection of prilocaine after 4 days. b Differential density of DCs in different skin compartments. Immunohistochemistry with staining of S-100 antigen. Left Overview of the skin layers with declining density of S-100 positive antigen-presenting cells from epidermis to subcutaneous tissue. Magnification 4 ×. Upper right High density of epidermal dendritic cells (Langerhans cells) in epidermis, papillary dermis and reticular dermis. Magnification 40 ×. Lower right In deeper subcutaneous compartments, dermal interstitial S-100 positive DCs are not detectable. Magnification 40 ×.