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Table 3 Types of hypersensitivity reactions [6, 7]

From: An introduction to immunology and immunopathology

Type Alternate name Examples Mediators
I Allergy (immediate) Atopy
• — Anaphylaxis
• — Asthma
• — Allergic rhinitis
• — Angioedema
• — Food allergy
IgE
II Cytotoxic, antibody-dependent Erythroblastosis fetalis
• Goodpasture’s syndrome
• Autoimmune anemias, thrombocytopenias
IgG, IgM
III Immune complex disease Systemic lupus erythematosus
• Serum sickness
• Reactive arthritis
• Arthrus reaction
Aggregation of antigens IgG, IgM Complement proteins
IV Delayed-type hypersensitivity, cell-mediated, antibody-independent Contact dermatitis
• Tuberculosis
• Chronic transplant rejection
T cells, monocytes, macrophages