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Table 2 Antihistamines commonly used and indicated for the treatment of urticaria.

From: Urticaria and angioedema

  Usual adult dose Usual pediatric dose
Second-generation H1-receptor antihistamines (first-line therapy)
Cetirizine (Reactine) 10-40 mg daily 5-10 mL (1-2 teaspoons) daily (children’s formulation)
Desloratadine (Aerius) 5-20 mg daily 2.5-5 mL (0.5-1.0 teaspoon) daily (children’s formulation)
Fexofenadine (Allegra) 120-480 mg daily Not currently indicated for children under 12 years of age
Loratadine (Claritin) 10-40 mg daily 5-10 mL (1-2 teaspoons) daily (children’s formulation)
First-generation H1-receptor antihistamines (best used as adjunctive therapy for patients with nocturnal symptoms)
Hydroxyzine (Atarax) 25-50 mg, three to four times daily Children < 6 years: 30 to 100 mg daily in divided doses
Diphenhydramine (Benadryl) 25-50 mg, every -6 hours 2.5-20 mL (0.5-4 teaspoons) every 4 to 6 hours (depending on age/weight)
Cyproheptadine (Periactin) 4-20 mg daily 2-4 mg, two to three times daily (depending on age/weight)
Chlorpheniramine (Chor-Tripolon) 4 mg every 4–6 hours 1 mg every 4–6 hours
Clemastine (Tavist-1) 1.34 - 2.68 mg, two to three times daily 1.34 mg, once or twice daily