Figure 4

Equivalent passive systemic anaphylaxis induction in L-sel^−/− and IL7R^−/− mice. Mice were initially injected i.v. with anti-DNP IgE to simulate sensitization. The next day, mice were injected i.v. with DNP-HSA to induce passive systemic anaphylaxis. Body temperature measurements in L-sel^−/− (A) and IL7R^−/− (D) mice were taken at 5-minute intervals for 60 minutes post-injection. We identified maximal individual temperature decreases (B, E) and assessed serum histamine levels (C, F) in animals sacrificed 5 minutes post-injection. (n = 4-5, *represents p < 0.05; **represents p < 0.01; Error bars = SEM)