Allergic anaphylaxis due to subcutaneously injected heparin

Table 1 Skin prick testing with UFH, LMWHs, heparinoids and fondaparinux

Drug tested	Wheal diameter [mm]
Heparin-sodium 25.000 I.E./ml	3
Nadroparin (Fraxiparin™) 9.500 I.E./ml	4
Dalteparin (Fragmin™) 12.500 I.E./ml	0
Enoxaparin (Clexane™) 10.000 I.E./ml	6 and pseudopodes
Danaparoid (Orgaran™) 1.250 I.E./ml	3
Pentosan polysulfate (Fibrezym™) 100 mg/ml	0
Fondaparinux (Arixtra™) 5 mg/ml	4
Sodium chloride 0.9% solution	0
Histamine 10 mg/ml	5

Reading at 20 minutes. Each test was performed with the undiluted heparin preparations, i.e. the pure therapeutic heparin solution.

ISSN: 1710-1492