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Table 2 Association between maternal factors and child total IgE or IL-5 over time

From: The development of TH2 responses from infancy to 4 years of age and atopic sensitization in areas endemic for helminth infections

Variables

Total IgE

IL5 PHA

IL5 BmA

IL5 Asc

 

crude β (95%CI)

adj β* (95%CI)

crude OR (95%CI)

adj OR* (95%CI)

crude OR (95%CI)

adj OR* (95%CI)

crude OR (95%CI)

adj OR* (95%CI)

Maternal filaria

        

No

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Yes

0.06

0.04

1.17

1.04

1.67

1.64

1.68

1.69

 

(−0.04, 0.17)

(−0.08, 0.16)

(0.87, 1.57)

(0.76, 1.41)

(1.20, 2.33)

(1.14, 2.36)

(1.15, 2.46)

(1.11, 2.58)

P value

0.24

0.51

0.30

0.81

0.003

0.008

0.007

0.01

P-int**

NT

NT

NT

NT

0.049

0.04

0.52

0.50

Maternal STHs

        

No

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Yes

0.08

0.05

0.87

0.83

1.00

0.91

1.07

0.97

 

(−0.02, 0.18)

(−0.05, 0.15)

(0.65, 1.18)

(0.61, 1.13)

(0.74, 1.36)

(0.67, 1.23)

(0.76, 1.50)

(0.69, 1.38)

P value

0.12

0.32

0.38

0.23

1.00

0.54

0.69

0.89

P-int**

NT

NT

NT

NT

NT

NT

NT

NT

Village of residence

        

Jati Sampurna

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

JatiKarya

−0.13

−0.21

1.10

1.11

1.08

0.97

0.93

0.84

 

(−0.93, 0.67)

(−0.41, -0.01)

(0.83, 1.45)

(0.83, 1.49)

(0.81, 1.44)

(0.70, 1.34)

(0.67, 1.28)

(0.60, 1.19)

P value

0.29

0.04

0.50

0.47

0.62

0.87

0.65

0.33

P-int**

NT

0.30

NT

NT

NT

NT

NT

NT

Socioeconomic status

        

High

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Low

0.13

0.12

1.44

1.47

1.20

1.16

1.39

1.20

 

(0.04, 0.22)

(0.02, 0.21)

(1.10, 1.87)

(1.11, 1.95)

(0.89, 1.61)

(0.86, 1.58)

(1.02, 1.91)

(0.86, 1.68)

P value

0.006

0.02

0.007

0.007

0.23

0.33

0.04

0.28

P-int**

0.20

0.11

0.61

0.61

NT

NT

0.50

NT

Maternal education

        

High

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Low

0.16

0.15

1.08

0.93

1.02

0.87

1.43

1.22

 

(0.07, 0.25)

(0.05, 0.25)

(0.81, 1.43)

(0.67, 1.27)

(0.75, 1.40)

(0.63, 1.21)

(1.03, 1.98)

(0.88, 1.70)

P value

0.001

0.003

0.60

0.63

0.89

0.42

0.03

0.23

P-int**

0.07

0.03

NT

NT

NT

NT

0.03

NT

  1. *Adjusted for other factors including child gender.
  2. ** P-int: P value on the interaction between time and the corresponding variable.
  3. P value in bold if significant (< 0.05).
  4. Adj: adjusted, OR: odds ratio, Ref: reference, NT: Not tested.
  5. STH: soil-transmitted helminth, PHA: phytohemagglutinin, BmA: Brugia malayi adult worm antigen, Asc: Ascaris adult worm antigen.
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Allergy, Asthma & Clinical Immunology

ISSN: 1710-1492

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