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Table 4 Participant ratings of overall effectiveness of the medication

From: A four-way, double-blind, randomized, placebo controlled study to determine the efficacy and speed of azelastine nasal spray, versus loratadine, and cetirizine in adult subjects with allergen-induced seasonal allergic rhinitis

  Placebo Cetirizine Loratadine Azelastine
  (N = 66) (N = 66) (N = 66) (N = 66)
Very good 6 (9%) 14 (21%) 8 (12%) 11 (17%)
Good 6 (9%) 20 (30%) 12 (18%) 19 (29%)
Satisfactory 10 (15%) 20 (30%) 22 (33%) 21 (32%)
Insufficient 44 (67%) 12 (18%) 24 (36%) 15 (23%)
Mean 3.4 2.5 2.9 2.6
Std. 0.99 1.03 1.02 1.02
Median 4.0 2.0 3.0 3.0
Min. to Max. 1-4 1-4 1-4 1-4
P value vs. placebo   <0.001 0.003 <0.001
  1. P-values and estimates obtained from a mixed effects cumulative logit proportional odds model with fixed effects for sequence, period, and treatment and random effects for subject within sequence.