Skip to main content

Table 10 General strategies for the prevention of GC-induced AEs

From: A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy

• Treat pre-existing comorbid conditions that may increase risk of GC-associated AEs
• Prescribe lowest effective GC dose for minimum period of time required to achieve treatment goals
• Administer as single daily dose (given in the morning), if possible
• Consider intermittent or alternate-day dosing, if possible
• Use GC-sparing agents whenever possible (e.g., omalizumab in severe asthma, azathioprine/cyclophosphamide in vasculitis, methotrexate in rheumatoid arthritis)
• Advise patients to:
 ▪ Carry a steroid treatment card
 ▪ Seek medical attention if they experience mood or behavioural changes
 ▪ Avoid contact with persons that have infections, such as shingles, chickenpox, or measles (unless they are immune)
 ▪ Not discontinue GC therapy abruptly unless advised to do so by their physician
 ▪ Adopt lifestyle recommendations to minimize the risk of weight gain or other AEs:
  ▫ Eat a healthy balanced diet, including adequate calcium intake
  ▫ Smoking cessation
  ▫ Reduction in alcohol consumption
  ▫ Regular physical activity
• Regularly monitor for signs/symptoms of AEs
  1. GC glucocorticoid, AEs adverse events.