Table 9 Canadian Cardiovascular Society guidelines for CVD prevention and dyslipidemia management: treatment thresholds and targets based on Framingham Risk Score (FRS)[125]
Risk level | Initiate therapy if: | Primary target LDL-C | Alternate target |
|---|---|---|---|
High | • Consider treatment in all | • ≤2 mmol/L, or | • Apo B ≤0.8 g/L |
FRS ≥20% |  | • ≥50% ↓ in LDL-C | • Non HDL-C ≤2.6 mmol/L |
Intermediate | • LDL-C ≥3.5 mmol/L | • ≤2 mmol/L,or | • Apo B ≤0.8 g/L |
FRS = 10%-19% | • For LDL-C <3.5 consider if: | • ≥50% ↓ in LDL-C | • Non HDL-C ≤2.6 mmol/L |
|  |   → Apo B ≥1.2 g/L, or |  |  |
|  |   → Non-HDL-C ≥4.3 mmol/L |  |  |
Low | • LDL-C ≥5.0 mmol/L | • ≥50% ↓ in LDL-C |  |
FRS <10% | • Familial hypercholesterolemia |  |  |