Cytokine production in cells with ORMDL3 knockdown. A) Secreted IL-6 and B) IL-8 levels after cell stimulation. 1HAE cells were stimulated with TNF-α, LPS, flagellin, or IL-1β for 24 hours. Data represent the mean ± SEM of three experimental repeats. Statistical analysis was performed using one-way ANOVA with Bonferroni post-test.