Staphylococcal enterotoxin B influences the DNA methylation pattern in nasal polyp tissue: a preliminary study

Table 2 Biological pathway analysis of the 43 top ranked genes showing differential methylation after simulation with SEB

*P-value*	Number of genes mapping the pathway	Total number of genes in the pathway	Pathway identifier	Pathway name	Genes mapping to the pathway
0,004	2	58	REACT_118823	Cytosolic sensors of pathogen-associated DNA	IKBKB, POLR3E
0,012	2	110	REACT_22232	Signaling by interleukins	STAT5B, IKBKB
0,013	2	115	REACT_6966	Toll-like receptors cascades	LGMN, IKBKB
0,015	2	120	REACT_121315	Glycosaminoglycan metabolism	STAB2, NDST1
0,015	2	120	REACT_147739	MPS IX - Natowicz syndrome	STAB2, NDST1
0,015	2	120	REACT_147853	Mucopolysaccharidoses	STAB2, NDST1
0,015	2	120	REACT_147788	MPS IIIB - Sanfilippo syndrome B	STAB2, NDST1
0,015	2	120	REACT_147719	MPS VI - Maroteaux-Lamy syndrome	STAB2, NDST1
0,015	2	120	REACT_147825	MPS IV - Morquio syndrome A	STAB2, NDST1
0,015	2	120	REACT_147860	MPS IIIC - Sanfilippo syndrome C	STAB2, NDST1
0,015	2	120	REACT_147759	MPS VII - Sly syndrome	STAB2, NDST1
0,015	2	120	REACT_147734	MPS II - Hunter syndrome	STAB2, NDST1
0,015	2	120	REACT_147857	MPS I - Hurler syndrome	STAB2, NDST1
0,015	2	120	REACT_147749	MPS IIID - Sanfilippo syndrome D	STAB2, NDST1
0,015	2	120	REACT_147753	MPS IIIA - Sanfilippo syndrome A	STAB2, NDST1
0,015	2	120	REACT_147798	MPS IV - Morquio syndrome B	STAB2, NDST1
0,045	4	915	REACT_116125	Disease	STAT5B, STAB2, NDST1, CYBA

All genes used in the analysis showed a likelihood of treatment related effect > 0,4. P-value: un-adjusted, not corrected for multiple testing, representing the probability (from hypergeometric test) of finding a given number or more genes in each pathway by chance.

ISSN: 1710-1492