Gene | UniProt | Pathway name | Sub-pathways | Biological function |
---|---|---|---|---|
ID | (Reactome) | (Reactome) | (UniProt) | |
IKBKB | O14920 | Cytosolic sensors of pathogen-associated DNA | ZBP1 mediated induction of type I Interferons | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. It is involved in the transcriptional regulation of genes involved in immune response, growth control, or protection against apoptosis. May prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. |
Adaptative immune response | TCR signaling | |||
Signaling by interleukins | IL-1 signaling | |||
Toll-Like receptors cascades | TLR2, TLR3, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10 | |||
POLR3E | Q9NVU0 | Cytosolic sensors of pathogen-associated DNA | Transcription of microbial dsDNA to dsRNA | Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. |
STAT5B | P51692 | Signaling by interleukins | Signaling of IL-2, IL-3, IL-5, IL-7 and GMCSF | Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. |
LGMN | Q99538 | Toll-Like receptors cascades | Trafficking and processing of endosomal TLR | It is involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. |