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Table 3 Sub-pathways and biological functions of the most representative genes showing hyper-methylation after stimulation with SEB

From: Staphylococcal enterotoxin B influences the DNA methylation pattern in nasal polyp tissue: a preliminary study

Gene

UniProt

Pathway name

Sub-pathways

Biological function

 

ID

(Reactome)

(Reactome)

(UniProt)

IKBKB

O14920

Cytosolic sensors of pathogen-associated DNA

ZBP1 mediated induction of type I Interferons

Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. It is involved in the transcriptional regulation of genes involved in immune response, growth control, or protection against apoptosis. May prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs.

  

Adaptative immune response

TCR signaling

 
  

Signaling by interleukins

IL-1 signaling

 
  

Toll-Like receptors cascades

TLR2, TLR3, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10

 

POLR3E

Q9NVU0

Cytosolic sensors of pathogen-associated DNA

Transcription of microbial dsDNA to dsRNA

Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.

STAT5B

P51692

Signaling by interleukins

Signaling of IL-2, IL-3, IL-5, IL-7 and GMCSF

Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription.

LGMN

Q99538

Toll-Like receptors cascades

Trafficking and processing of endosomal TLR

It is involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.

  1. The genes for this analysis were selected from the Reactome over-representation pathway analysis.