Figure 2

Comparing QAC (Queen’s University only) and CAC studies. A and B. Mean TNSS and PNIF scores including non-allergic participants. Allergic participants experienced the highest scores at 15 minutes (QAC TNSS: 15 minutes vs 4 and 5 hour time point p<0.05, vs 6^th hour to 12^th hour p<0.001) (CAC TNSS: 15 minutes vs 2 hour p<0.05, vs 3 to 12^th hour p<0.001) compared to non-allergic participants who did not experience change from baseline. Most time points were significantly greater than baseline scores (QAC: Baseline TNSS vs 15 minutes to 3 hours p< 0.001 and p<0.01 at the 4^th and 5^th hours) (CAC: Baseline TNSS vs 15 minutes to 2 hours p<0.001, vs 3^rd hour p<0.01, vs 4^th hour p<0.05). PNIF scores followed a similar pattern (QAC PNIF: Baseline vs 15 and 30 minutes p<0.001, vs 1 hour p<0.01; while 15 minutes time point vs 3 hours to the 12^th hour p<0.001) (CAC PNIF: Baseline time point vs 15 minutes up to 1 hour p<0.001 and vs 2 hours p<0.05; while the 15 minute time point vs 3 hours p<0.05, vs 5^th to the 7^th hour p<0.01, 8^th hour p<0.001, 9^th to the 11^th hour p<0.01, and 12^th hour p<0.001). While there were significant differences between the time points for allergic participants (two way ANOVA p<0.0001 for both TNSS and PNIF in both studies), there were no such significance experienced by non-allergic participants. C - D: Strong correlation between TNSS and PNIF exists in both studies, although the correlation is stronger in the CAC study (Person’s correlation QAC: R²=0.8981 p<0.0001, CAC: R²=9576 p<0.0001).