Participants divided based on the phases of AR experienced based on TNSS. Participants in the QAC (Figure 3
A) and CAC (Figure 3
B) studies who had an Early Phase Responders (EPR) and Dual Phase Responders (DPR) experienced a peak at 15 min. following NAC while those that experienced a protracted EPR (pEPR) had a gradual rise in TNSS up to 1 hr. This suggests that the 1hr time point ensures that the maximal amount of cytokines are secreted by this time point in all participants and therefore is the best time point for sampling nasal cytokines. While EPR experienced a drop in TNSS following the peak, pEPR maintained their symptoms level before declining, DPR experienced a drop in TNSS following the peak but did rise again later in the study. Statistical analysis was not possible since participant populations experiencing certain phases were too small to compare. Nevertheless, differences in scores over the 12 hour period were distinct from one participant population to the other.