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Table 1 The number of inflammatory cells, expression of cytokines and transcription factors in normalized relative quantities (NRQ), described as median (IQR) in the tissue of nasal polyps of ECRS and non-ECRS patients, and normal controls

From: T-cell phenotypes in chronic rhinosinusitis with nasal polyps in Japanese patients

Nasal tissue analysis

Eosinophilic CRS polyps

Non-eosinophilic CRS polyps

Non-CRS controls

Multiple comparison

ECRS vs NC

ECRS vs non-ECRS

Non-ECRS vs NC

Median (IQR)

Median (IQR)

Median (IQR)

P-value

P-value

P-value

P-value

The number of inflammatory cells

     

 Eosinophils

127.4 (81.4–180.7)

2.5 (0.55–7.3)

0 (0–0.05)

<0.001

<0.001

<0.001

0.0082

 T cells (CD3)

29.8 (27.7–72.1)

60.5 (34.6–113.0)

56.2 (37.1–66.3)

0.34

0.52

0.14

0.74

 CD4+ cells

3.4 (2.3–7.3)

16.4 (10.0–24.2)

13.3 (10.3–16.5)

0.0016

0.005

0.0014

0.42

 CD8+ cells

36.6 (16.2–56.1)

63.2 (42.9–82.1)

34.4 (23.4–58.0)

0.029

0.67

0.022

0.038

mRNA expression of transcription factors

     

 Tbet

0.85 (0.5–1.4)

2.5 (1.2–113.2)

1.7 (1.1–2.7)

0.06

0.17

0.03

0.28

 GATA3

0.56 (0.33–0.73)

1.2 (0.54–39.9)

1.0 (0.9–1.9)

0.018

0.003

0.0049

0.92

 FOXP3

2.3 (1.9–3.2)

10.0 (6.2–30.8)

2.1 (1.0–4.5)

<0.001

1

<0.001

0.005

 RORc

0.37 (0.096–0.49)

0.66 (0.48–10.9)

1.1 (0.91–1.56)

0.007

0.0025

0.0023

0.56

mRNAexpression of key cytokines

 IFN-γ

0.77 (0.28–1.2)

5.2 (1.4–16.4)

1.4 (0.81–2.2)

0.003

0.25

0.0015

0.04

 IL-5

137.8 (21.3–573.5)

0.11 (0.0–1.1)

0.39 (0.069–1.0)

<0.001

<0.001

<0.001

0.88

 IL-13

16.5 (3.9–61.3)

0.3 (0.0–4.5)

0.81 (0.11–3.6)

<0.001

0.006

<0.001

0.67

 IL-4

0.62 (0.19–0.98)

0.3 (0.095–0.89)

0.78 (0.17–1.3)

0.58

0.79

0.39

0.38

 IL-4R

0.052 (0.036–0.88)

0.11 (0.067–0.27)

0.24 (0.11–0.67)

<0.001

<0.001

0.03

0.04

 IL-10

5.3 (2.5–8.1)

8.9 (4.0–268.4)

1.0 (0.93–2.4)

0.005

0.04

0.13

0.002

 TGF-β1

2.9 (1.9–4.0)

6.1 (3.6–17.6)

2.4 (1.5–2.9)

0.007

0.28

0.02

0.005

 IL-17

4.1 (1.3–12.3)

22.0 (8.3–4534.0)

4.0 (1.6–8.2)

0.042

0.92

0.03

0.03

  1. P < 0.05 were considered to indicate statistical significance (italic values)
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Allergy, Asthma & Clinical Immunology

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