Fig. 4

JNK and p42/p44 ERK inhibitors decrease TNF-mediated PTX3 protein expression. PTX3 protein released by HASMC treated with TNF (10 ng/ml) for 24 h with or without pretreatment inhibitors of JNK (SP600125, 50 nM), p42/p44 ERK (U0126, 10 μM) and p38 MAPK (SB203580, 10 μM) was determined by ELISA. *P < 0.05, ***P < 0.001 was compared with TNF-stimulated alone