From: Post-vaccination myositis and myocarditis in a previously healthy male
 | Exposure to an external stimuli (Infection, vaccine, silicone, adjuvant) prior to clinical manifestations |
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Major criteria | The appearance of ’typical’ clinical manifestations: |
  Myalgia, Myositis or muscle weakness | |
 Arthralgia and/or arthritis | |
  Chronic fatigue, un-refreshing sleep or sleep disturbances | |
 Neurological manifestations (especially associated with demyelination) | |
 Cognitive impairment, memory loss | |
 Pyrexia, dry mouth | |
Removal of inciting agent induces improvement | |
Typical biopsy of involved organs | |
Minor criteria | The appearance of autoantibodies or antibodies directed at the suspected adjuvant |
Other clinical manifestations (i.e. irritable bowel syn.) | |
Specific HLA (i.e. HLA DRB1, HLA DQB1) | |
Evolvement of an autoimmune disease (i.e. MS, SSc) |